A Potent Inhibitor of Inducible Nitric Oxide Synthase, ONO-1714, a Cyclic Amidine Derivative

Masao Naka, Toshiyuki Nanbu, Kaoru Kobayashi, +11

Biochemical and Biophysical Research Communications

BiochemistryPotent InhibitorCyclic Amidine DerivativeMedicineNatural Sciences +7

The synthesis of potent thromboxane A2/ prostaglandin endoperoxide receptor antagonist

Nobuyuki Hamanaka, Takuya Seko, T. Miyazaki, +3

Tetrahedron Letters

BiochemistryMedicineMechanism Of ActionPharmacological AgentExperimental Pharmacology +3

A specific inducible nitric oxide inhibitor, ONO‐1714 attenuates inflammation‐related large bowel carcinogenesis in male <i>Apc</i>^Min/+ mice

Hiroyuki Kohno, Mami Takahashi, Yumiko Yasui, +7

International Journal of Cancer

Chemoprevention StrategyGastrointestinal PharmacologyImmunologyGastroenterologyPathology +15

Suppressive effect of an inducible nitric oxide inhibitor, ONO-1714, on AOM-induced rat colon carcinogenesis

Mami Takahashi, Michihiro Mutoh, Yutaka Shoji, +6

Nitric Oxide

OncologyMedicineColorectal CancerPathologyTumor Suppressor +4

Novel synthesis and biochemical properties of an [125I]-labeled photoaffinity probe for thromboxane A2/prostaglandin H2 receptors

Dale E. Mais, Nancy Bowling, Timothy A. True, +5

Journal of Medicinal Chemistry

Altmetric Attention ScorePharmacotherapyNovel SynthesisChemical BiologyOptogenetics +15

Effects of ONO-3708, an antagonist of the thromboxane A2/prostaglandin endoperoxide receptor, on platelet aggregation and thrombosis

Kigen Kondo, Rumi Seo, Masao Naka, +6

European Journal of Pharmacology

InflammationThrombosisThrombopoiesisCardiovascular DiseaseBlood Platelet +11

Transfection of K-rasAsp12 cDNA markedly elevates IL-1β- and lipopolysaccharide-mediated inducible nitric oxide synthase expression in rat intestinal epithelial cells

Mami Takahashi, Michihiro Mutoh, Yutaka Shoji, +5

Oncogene

InflammationCytokineSignal TransductionMucosal ImmunologyImmune Cell Development +7

Design and synthesis of inhibitors of inducible nitric oxide synthase. Discovery of a new chemical lead with potential for oral bioavailability

Yasufumi Kawanaka, Kaoru Kobayashi, Shinya Kusuda, +10

European Journal of Medicinal Chemistry

Medicinal ChemistryOral BioavailabilityNew Chemical LeadBiochemistryReactive Nitrogen Specie +7

Design and Synthesis of Orally Bioavailable Inhibitors of Inducible Nitric Oxide Synthase. Identification of 2-Azabicyclo[4.1.0]heptan-3-imines

Yasufumi Kawanaka, Kaoru Kobayashi, Shinya Kusuda, +11

Bioorganic & Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryBiochemistryReactive Nitrogen SpecieMedicine +10

Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. synthesis and biological evaluation of dihydropyridin-2(1H)-imines and 1,5,6,7-Tetrahydro-2H-azepin-2-imines

Yasufumi Kawanaka, Kaoru Kobayashi, Shinya Kusuda, +11

Bioorganic & Medicinal Chemistry

Medicinal ChemistryBiochemistryReactive Nitrogen SpecieNatural SciencesMedicine +8