Design and Synthesis of Potent and Highly Selective Thrombin Inhibitors

Kurt Hilpert, Jean Ackermann, David W. Banner, +8

Journal of Medicinal Chemistry

Structural Basis for Allosteric Ligand Recognition in the Human CC Chemokine Receptor 7

K. Jaeger, S. Bruenle, Tobias Weinert, +16

Cell

Epidermal growth factor receptor targeting enhances adenoviral vector based suicide gene therapy of osteosarcoma

M.A. Witlox, Victor W. van Beusechem, Jacques Grill, +9

The Journal of Gene Medicine

Thrombin plays a key role in late platelet thrombus growth and/or stability. Effect of a specific thrombin inhibitor on thrombogenesis induced by aortic subendothelium exposed to flowing rabbit blood.

Alain Gast, T. Tschopp, HR Baumgartner

Arteriosclerosis and Thrombosis A Journal of Vascular Biology

Key RoleRabbit BloodImmunologySpecific Thrombin InhibitorShear Rate +18

Inhibition of clot-bound and free (fluid-phase thrombin) by a novel synthetic thrombin inhibitor (Ro 46-6240), recombinant hirudin and heparin in human plasma

Alain Gast, T. Tschopp, Georg H. Schmid, +2

Blood Coagulation & Fibrinolysis

Activated Clotting Time as an Appropriate Test to Compare Heparin and Direct Thrombin Inhibitors Such as Hirudin or Ro 46-6240 in Experimental Arterial Thrombosis

Jean Pierre Carteaux, Alain Gast, Thomas B. Tschopp, +1

Circulation

The Elastase Inhibitory Capacity and the α_<b>1</b>-Proteinase Inhibitor and Bronchial Inhibitor Content of Bronchoalveolar Lavage Fluids from Healthy Subjects

Christian Boudier, A Pelletier, Alain Gast, +3

Biological Chemistry Hoppe-Seyler

AsthmaInflammatory Lung DiseaseHealthy SubjectsLung InflammationAdvanced Lung Disease +15

Mapping the conformational space accessible to BACE2 using surface mutants and cocrystals with Fab fragments, Fynomers and Xaperones

David W. Banner, Bernard Gsell, Jörg Benz, +22

Acta Crystallographica Section D Biological Crystallography

X-ray CrystallographyCrystal StructureProtein SecretionTransmembrane Protein Tmem27Molecular Biology +19

Pharmacokinetics and Distribution of Recombinant Secretory Leukocyte Proteinase Inhibitor in Rats

Alain Gast, Wayne H. Anderson, A. Probst, +4

American Review of Respiratory Disease

Proteolytic activity in the culture supernatants of mouse hybridoma cells.

Schlaeger Ej, Bernhard Eggimann, Alain Gast

PubMed

OocyteImmunologyCell CultureCell ProliferationCellular Physiology +14