A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles

Aravind Subramanian, Rajiv Narayan, Steven M. Corsello, +53

Cell

Network ScienceEngineeringData ScienceEdge ComputingComputer Engineering +10

Virus Infection Induces the Assembly of Coordinately Activated Transcription Factors on the IFN-β Enhancer In Vivo

Marc Wathelet, Charles Lin, Bhavin S. Parekh, +3

Molecular Cell

Transcriptional RegulationViral ReplicationVirus InfectionImmunologyGene Expression +9

Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity

Lucienne Ronco, Alla Y. Karpova, Marc Vidal, +1

Genes & Development

Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy

Moran Dvela‐Levitt, Maria Kost‐Alimova, Maheswarareddy Emani, +35

Cell

Protein FunctionAutoimmune DiseaseMedicineNatural SciencesT-regulatory Cell +7

Binding of TMPRSS2-ERG to BAF Chromatin Remodeling Complexes Mediates Prostate Oncogenesis

Gabriel J. Sandoval, John L. Pulice, Hubert Pakula, +16

Molecular Cell

ChromatinTranscriptional RegulationSignal TransductionChromatin StructureChromatin Remodeling +8

A Next Generation Connectivity Map: L1000 Platform And The First 1,000,000 Profiles

Aravind Subramanian, Rajiv Narayan, Steven M. Corsello, +49

EngineeringGeneticsMolecular BiologyNetwork AnalysisNetwork Computing +25

A Small Molecule That Binds and Inhibits the ETV1 Transcription Factor Oncoprotein

Marius S. Pop, Nicolas Stransky, Colin W. Garvie, +11

Molecular Cancer Therapeutics

Molecular BiologyTumor BiologyCancer-associated VirusTranscriptional RegulationEts Factor Gene +17

Functional Characterization of Interferon Regulatory Factor 3a (IRF-3a), an Alternative Splice Isoform of IRF-3

Alla Y. Karpova, Lucienne Ronco, Peter M. Howley

Molecular and Cellular Biology

Identification of a gene encoding a human oxysterol-binding protein-homologue: a potential general molecular marker for blood dissemination of solid tumors.

Marcia V. Fournier, Fernanda C. Guimaraes, Marcos Eduardo Machado Paschoal, +1

PubMed

Solid TumorsPathologyBlood DisseminationCancer BiologyTumor Biology +17

Discovery of (+)-<i>N</i>-(3-Aminopropyl)-<i>N</i>-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-<i>d</i>]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a Kinesin Spindle Protein Inhibitor and Potential Anticancer Agent

Maria‐Elena Theoclitou, Brian Aquila, M. Block, +22

Journal of Medicinal Chemistry