Opening of the mitochondrial permeability transition pore causes matrix expansion and outer membrane rupture in fas-mediated hepatic apoptosis in mice

Gérard Feldmann, D. Haouzi, Alain Moreau, +6

Hepatology

Hepatotoxicity of the Herbal Medicine Germander: Metabolic Activation of Its Furano Diterpenoids by Cytochrome P450 3A Depletes Cytoskeleton–Associated Protein Thiols and Forms Plasma Membrane Blebs in Rat Hepatocytes

Mounia Lekéhal, Dominique Pessayre, J M Lereau, +3

Hepatology

Diterpenoids from germander, an herbal medicine, induce apoptosis in isolated rat hepatocytes

Daniel Fau, Mounia Lekéhal, A. Moreau, +4

Gastroenterology

Isolated Rat HepatocytesMedicineLiver PhysiologyHerbal MedicineImmunology +8

Toxicity of the antiandrogen flutamide in isolated rat hepatocytes.

Daniel Fau, Daniel Eugène, Alain Berson, +4

Journal of Pharmacology and Experimental Therapeutics

Hepatotoxicity of germander in mice

Jacqueline Loeper, Véronique Descatoire, Philippe Lettéron, +5

Gastroenterology

HepatologyRodent-borne DiseasesMedicineLiver PhysiologyToxicology +5

Toxicity of Alpidem, a Peripheral Benzodiazepine Receptor Ligand, but Not Zolpidem, in Rat Hepatocytes: Role of Mitochondrial Permeability Transition and Metabolic Activation

Alain Berson, Véronique Descatoire, Angéla Sutton, +7

Journal of Pharmacology and Experimental Therapeutics

Cytochrome P450-generated reactive metabolites cause mitochondrial permeability transition, caspase activation, and apoptosis in rat hepatocytes

D. Haouzi, Mounia Lekéhal, Alain Moreau, +6

Hepatology

Lipid PeroxidationApoptosisMitochondrial Permeability TransitionCell DeathRedox Biology +17

Mechanisms for experimental buprenorphine hepatotoxicity: major role of mitochondrial dysfunction versus metabolic activation

Alain Berson, Daniel Fau, Roxane Fornacciari, +8

Journal of Hepatology

Experimental Buprenorphine HepatotoxicityOxysterolBiochemistryMitochondrial FunctionMitochondrial Dysfunction +12

Mechanism for the hepatotoxicity of the antiandrogen, nilutamide. Evidence suggesting that redox cycling of this nitroaromatic drug leads to oxidative stress in isolated hepatocytes.

Daniel Fau, Alain Berson, Daniel Eugène, +3

Journal of Pharmacology and Experimental Therapeutics

Uncoupling of rat and human mitochondria: A possible explanation for tacrine-induced liver dysfunction

Alain Berson, Sylvaine Renault, P Lettéron, +8

Gastroenterology

HepatologyBiochemistryMitochondrial FunctionMedicineLiver Physiology +13