Alpha-cell-specific expression of the glucagon gene is conferred to the glucagon promoter element by the interactions of DNA-binding proteins.

Jan Philippé, Daniel J. Drucker, W Knepel, +3

Molecular and Cellular Biology

GeneticsMolecular GeneticsCellular PhysiologyInsulin SignalingTranscriptional Regulation +17

Membrane depolarization and calcium influx induce glucagon gene transcription in pancreatic islet cells through the cyclic AMP-responsive element.

Markus Schwaninger, G Lux, R Blume, +3

Journal of Biological Chemistry

Cellular PhysiologyCalcium-dependent Action PotentialsInsulin SignalingSignaling PathwayHyperpolarization (Biology) +18

Transcriptional activation of the rat glucagon gene by the cyclic AMP-responsive element in pancreatic islet cells.

W Knepel, J Chafitz, Joel F. Habener

Molecular and Cellular Biology

Transcriptional ActivationMolecular PhysiologyDevelopmental BiologySignal TransductionRat Glucagon Gene +13

Effects of a Kappa-Opioid Agonist on Adrenocorticotropic and Diuretic Function in Man

Andreas Pfeiffer, W Knepel, Sandra Braun, +3

Hormone and Metabolic Research

HypertensionPharmacotherapyMr 2034Diuretic FunctionAdrenal Gland +19

A pancreatic islet cell-specific enhancer-like element in the glucagon gene contains two domains binding distinct cellular proteins.

W Knepel, Lisa I. Jepeal, Joel F. Habener

Journal of Biological Chemistry

Insulin SignalingTranscriptional RegulationCell SignalingGlucagon PromoterTranscription Factors +14

Distinct properties of the cAMP-responsive element of the rat insulin I gene.

E. Oetjen, T Diedrich, Anke Eggers, +2

Journal of Biological Chemistry

Cellular PhysiologyInsulin SignalingTranscriptional RegulationCamp-responsive ElementProtein Expression +16

Inhibition of cAMP-responsive element-mediated gene transcription by cyclosporin A and FK506 after membrane depolarization.

Markus Schwaninger, R Blume, E. Oetjen, +2

Journal of Biological Chemistry

Molecular RegulationMolecular BiologyCyclosporin AComplex FormationCellular Physiology +16

Inhibition by antidepressant drugs of cyclic AMP response element-binding protein/cyclic AMP response element-directed gene transcription.

Markus Schwaninger, Christof Schöfl, R Blume, +2

Molecular Pharmacology

Inhibition of CREB- and cAMP response element-mediated gene transcription by the immunosuppressive drugs cyclosporin A and FK506 in T cells

Meike Krüger, Markus Schwaninger, Roland Blume, +2

Naunyn-Schmiedeberg s Archives of Pharmacology

Signal TransductionT CellsT-regulatory CellReceptor Tyrosine KinaseImmunology +7

Evidence for Inhibition by β-Endorphin of Vasopressin Release during Foot Shock-Induced Stress in the Rat

W Knepel, D. Nutto, G. Hertting

Neuroendocrinology

InflammationAdrenal GlandAnesthesiaStress HormoneSodium Homeostasis +11