Immunoconjugates containing novel maytansinoids: promising anticancer drugs.

R. V. J. CHARI, B. Martell, Janet L. Gross, +5

PubMed

Medicinal ChemistryActive DrugPolymer-drug ConjugateMedicineImmunology +10

Humanization of murine monoclonal antibodies through variable domain resurfacing.

Michael Roguska, Jim Thuesen Pedersen, C Keddy, +7

Proceedings of the National Academy of Sciences

Eradication of large colon tumor xenografts by targeted delivery of maytansinoids.

C. Liu, B. Mitra Tadayoni, Lizabeth A. Bourret, +9

Proceedings of the National Academy of Sciences

Tumor XenograftsSurgical OncologyTargeted DeliveryImmunologyPathology +15

Serotherapy of B-cell neoplasms with anti-B4-blocked ricin: a phase I trial of daily bolus infusion

ML Grossbard, AS Freedman, Jerome Ritz, +7

Blood

Expression of the receptor-linked protein tyrosine phosphatase LAR: proteolytic cleavage and shedding of the CAM-like extracellular region.

Michel Streuli, N. Krueger, P D Ariniello, +6

The EMBO Journal

Protein FunctionSignal TransductionProteolytic CleavageBiochemistrySignaling Pathway +10

Anti-B4-blocked ricin: a phase I trial of 7-day continuous infusion in patients with B-cell neoplasms.

Michael L. Grossbard, JM Lambert, V S Goldmacher, +7

Journal of Clinical Oncology

Purified immunotoxins that are reactive with human lymphoid cells. Monoclonal antibodies conjugated to the ribosome-inactivating proteins gelonin and the pokeweed antiviral proteins.

John M. Lambert, Peter D. Senter, A Yau-Young, +2

Journal of Biological Chemistry

An immunotoxin prepared with blocked ricin: a natural plant toxin adapted for therapeutic use.

JM Lambert, V S Goldmacher, Albert R. Collinson, +2

PubMed

Natural Plant ToxinToxinologyNatural ToxinsGlycobiologyImmunology +19

Enhancement of the selectivity and antitumor efficacy of a CC-1065 analogue through immunoconjugate formation.

R. V. J. CHARI, K A Jackel, Lizabeth A. Bourret, +7

PubMed

ImmunologyAntitumor EfficacyImmunotherapyTumor BiologyCc-1065 Analogue +14

Adjuvant immunotoxin therapy with anti-B4-blocked ricin after autologous bone marrow transplantation for patients with B-cell non- Hodgkin's lymphoma

ML Grossbard, JG Gribben, AS Freedman, +7

Blood