Infection of bat and human intestinal organoids by SARS-CoV-2

Jie Zhou, Cun Li, Xiaojuan Liu, +17

Nature Medicine

Active Replication of Middle East Respiratory Syndrome Coronavirus and Aberrant Induction of Inflammatory Cytokines and Chemokines in Human Macrophages: Implications for Pathogenesis

Jie Zhou, Hin Chu, Cun Li, +12

The Journal of Infectious Diseases

Differentiated human airway organoids to assess infectivity of emerging influenza virus

Jie Zhou, Cun Li, Norman Sachs, +15

Proceedings of the National Academy of Sciences

AllergyCounterpart H1n1swRespiratory DiseasesPathogenesisImmunology +11

Genome-wide association study identifies <i>NRG1</i> as a susceptibility locus for Hirschsprung's disease

María-Mercé García-Barceló, Clara Sze-Man Tang, Vincent Chi‐Hang Lui, +19

Proceedings of the National Academy of Sciences

Genome-wide association study identifies a susceptibility locus for biliary atresia on 10q24.2

María-Mercé García-Barceló, Ming-Yiu Yeung, Xiaoping Miao, +18

Human Molecular Genetics

Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity

Hin Chu, Huiping Shuai, Yuxin Hou, +22

Science Advances

InflammationIntrinsic Apoptosis PathwayDisease SeverityMedicineApoptosis +11

Common genetic variants regulating ADD3 gene expression alter biliary atresia risk

Guo Cheng, Clara Sze-Man Tang, Emily Hoi-Man Wong, +28

Journal of Hepatology

Allelic VariantGenetic DisorderMedicineGeneticsGenetic Epidemiology +10

Identification of a <i>HOXD13</i> mutation in a VACTERL patient

Maria‐Mercè Garcia‐Barceló, Kenneth Kak‐Yuen Wong, Vincent Chi‐Hang Lui, +5

American Journal of Medical Genetics Part A

Coronaviruses exploit a host cysteine-aspartic protease for replication

Hin Chu, Yuxin Hou, Dong Yang, +26

Nature

Viral ReplicationPathogenesisMolecular BiologyVirologyHost Cysteine-aspartic Protease +2

Hedgehog/Notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung disease in mice and humans

María-Mercé García-Barceló, Benjamin Hon Kei Yip, Hiu-Ching Poon, +10

Journal of Clinical Investigation

PathologyDisease Gene IdentificationHscr Susceptibility GenesSignaling PathwayEpendyma +16