Intrastriatal injection of preformed alpha-synuclein fibrils alters central and peripheral immune cell profiles in non-transgenic mice

Rachael H. Earls, Kelly B. Menees, Jaegwon Chung, +4

Journal of Neuroinflammation

NK cells clear α-synuclein and the depletion of NK cells exacerbates synuclein pathology in a mouse model of α-synucleinopathy

Rachael H. Earls, Kelly B. Menees, Jaegwon Chung, +6

Proceedings of the National Academy of Sciences

Peripheral Administration of the Selective Inhibitor of Soluble Tumor Necrosis Factor (TNF) XPro®1595 Attenuates Nigral Cell Loss and Glial Activation in 6-OHDA Hemiparkinsonian Rats

Christopher J. Barnum, Xi Chen, Jaegwon Chung, +5

Journal of Parkinson s Disease

Progranulin Does Not Bind Tumor Necrosis Factor (TNF) Receptors and Is Not a Direct Regulator of TNF-Dependent Signaling or Bioactivity in Immune or Neuronal Cells

Xi Chen, Jianjun Chang, Qiudong Deng, +13

Journal of Neuroscience

Regulator of G-Protein Signaling-10 Negatively Regulates NF-κB in Microglia and Neuroprotects Dopaminergic Neurons in Hemiparkinsonian Rats

Jae‐Kyung Lee, Jaegwon Chung, Fiona E McAlpine, +1

Journal of Neuroscience

Glial BiologySynaptic TransmissionImmunologyImmune RegulationCell Death +31

Candidate inflammatory biomarkers display unique relationships with alpha-synuclein and correlate with measures of disease severity in subjects with Parkinson’s disease

Lori N. Eidson, George T. Kannarkat, Christopher J. Barnum, +13

Journal of Neuroinflammation

Sex- and age‐dependent alterations of splenic immune cell profile and NK cell phenotypes and function in C57BL/6J mice

Kelly B. Menees, Rachael H. Earls, Jaegwon Chung, +4

Immunity & Ageing

InflammationLymphocyte DevelopmentImmune Cell DevelopmentAge‐dependent AlterationsAdaptive Immune System +10

Critical Role of Regulator G-Protein Signaling 10 (RGS10) in Modulating Macrophage M1/M2 Activation

Jae‐Kyung Lee, Jaegwon Chung, George T. Kannarkat, +1

PLoS ONE

ImmunologyImmune RegulationCd4 T Cell ResponsesInnate ImmunityImmune System +27

RGS10 exerts a neuroprotective role through the PKA/c‐AMP response‐element (CREB) pathway in dopaminergic neuron‐like cells

Jae‐Kyung Lee, Jaegwon Chung, Kirk M. Druey, +1

Journal of Neurochemistry

Role of Protein Phosphatases in Estrogen-Mediated Neuroprotection

Kun Yi, Jaegwon Chung, Priscilla Pang, +1

Journal of Neuroscience