Helmtrud I. Roach

Association between the abnormal expression of matrix‐degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the promoter regions

Helmtrud I. Roach, Norikazu Yamada, Kelvin Sin Chi Cheung et al. · Arthritis & Rheumatism · 2005 · 350 citations

Life Sciences, Molecular Biology, Molecular Genetics +16

Temporal Analysis of Rat Growth Plates: Cessation of Growth with Age Despite Presence of a Physis

Helmtrud I. Roach, Gautam Mehta, Richard O. C. Oreffo et al. · Journal of Histochemistry & Cytochemistry · 2003 · 177 citations · Full text

Medicine, Developmental Biology, Aging +16

Induction of Human Osteoprogenitor Chemotaxis, Proliferation, Differentiation, and Bone Formation by Osteoblast Stimulating Factor-1/Pleiotrophin: Osteoconductive Biomimetic Scaffolds for Tissue Engineering

Xuebin Yang, Rahul S. Tare, Kris Partridge et al. · Journal of Bone and Mineral Research · 2003 · 164 citations

Engineering, Bioengineering, Biomedical Engineering +17

DNA demethylation at specific CpG sites in the <i>IL1B</i> promoter in response to inflammatory cytokines in human articular chondrocytes

Ko Hashimoto, Richard O. C. Oreffo, Marc B. Gibson et al. · Arthritis & Rheumatism · 2009 · 162 citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +13

Regulated Transcription of Human Matrix Metalloproteinase 13 (MMP13) and Interleukin-1β (IL1B) Genes in Chondrocytes Depends on Methylation of Specific Proximal Promoter CpG Sites

Ko Hashimoto, Miguel Otero, Kei Imagawa et al. · Journal of Biological Chemistry · 2013 · 146 citations · Full text

Life Sciences, Genetics, Molecular Biology +16