Helmtrud I. Roach

Association between the abnormal expression of matrix‐degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the promoter regions

Helmtrud I. Roach, Norikazu Yamada, Kelvin Sin Chi Cheung et al. · Arthritis & Rheumatism · 2005 · 348 citations

Temporal Analysis of Rat Growth Plates: Cessation of Growth with Age Despite Presence of a Physis

Helmtrud I. Roach, Gautam Mehta, Richard O. C. Oreffo et al. · Journal of Histochemistry & Cytochemistry · 2003 · 174 citations · Full text

Temporal Analysis, Biogerontology, Cell Growth +21

Induction of Human Osteoprogenitor Chemotaxis, Proliferation, Differentiation, and Bone Formation by Osteoblast Stimulating Factor-1/Pleiotrophin: Osteoconductive Biomimetic Scaffolds for Tissue Engineering

Xuebin Yang, Rahul S. Tare, Kris Partridge et al. · Journal of Bone and Mineral Research · 2003 · 162 citations

DNA demethylation at specific CpG sites in the <i>IL1B</i> promoter in response to inflammatory cytokines in human articular chondrocytes

Ko Hashimoto, Richard O. C. Oreffo, Marc B. Gibson et al. · Arthritis & Rheumatism · 2009 · 161 citations · Full text

Regulated Transcription of Human Matrix Metalloproteinase 13 (MMP13) and Interleukin-1β (IL1B) Genes in Chondrocytes Depends on Methylation of Specific Proximal Promoter CpG Sites

Ko Hashimoto, Miguel Otero, Kei Imagawa et al. · Journal of Biological Chemistry · 2013 · 144 citations · Full text