A human liver microphysiology platform for investigating physiology, drug safety, and disease models

Lawrence A. Vernetti, Nina Senutovitch, Robert C. Boltz, +4

Experimental Biology and Medicine

A 3D microfluidic liver model for high throughput compound toxicity screening in the OrganoPlate®

Kristin M. Bircsak, Richard DeBiasio, Mark T. Miedel, +6

Toxicology

Control of oxygen tension recapitulates zone-specific functions in human liver microphysiology systems

Felipe T. Lee-Montiel, Subin M. George, Albert Gough, +5

Experimental Biology and Medicine

Quantification of G-Protein Coupled Receptor Internalization Using G-Protein Coupled Receptor-Green Fluorescent Protein Conjugates with the ArrayScan™ High-Content Screening System

Barbara R. Conway, Lisa Minor, Jun Xu, +8

SLAS DISCOVERY

Quantitative Cell-Based High-Content Screening for Vasopressin Receptor Agonists Using Transfluor®Technology

Richik N. Ghosh, Richard DeBiasio, Christine C. Hudson, +3

SLAS DISCOVERY

Comparison of wild-type and high-risk PNPLA3 variants in a human biomimetic liver microphysiology system for metabolic dysfunction-associated steatotic liver disease precision therapy

Mengying Xia, Mahboubeh Varmazyad, Iris Plá-Palacín, +15

Frontiers in Cell and Developmental Biology

A Quantitative Systems Pharmacology Platform Reveals NAFLD Pathophysiological States and Targeting Strategies

Daniel E. Lefever, Mark T. Miedel, Fen Pei, +15

Metabolites