1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells.

Kenta Hara, Kazuyoshi Yonezawa, Hiroshi Sakaue, +7

Proceedings of the National Academy of Sciences

Complex FormationInsulin SignalingCellular PhysiologySignaling PathwayReceptor Tyrosine Kinase +18

Involvement of phosphoinositide 3-kinase in insulin- or IGF-1-induced membrane ruffling.

K. Kotani, Kouichiro Yonezawa, Kenta Hara, +7

The EMBO Journal

Developmental BiologySignal TransductionMolecular PhysiologySignaling PathwayCell Signaling +8

Involvement of rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in cell motility.

Kenji Takaishi, Akira Kikuchi, Shinya Kuroda, +3

Molecular and Cellular Biology

Molecular BiologyCytoskeletonCellular PhysiologyRho GdiRhoa P21 +14

Requirement for Phosphoinositide 3-Kinase in Insulin-Stimulated GLUT4 Translocation in 3T3-L1 Adipocytes

K. Kotani, Amanda Carozzi, Hiroshi Sakaue, +6

Biochemical and Biophysical Research Communications

Phosphoinositide 3-KinaseMolecular PhysiologySignal TransductionBiochemistryNatural Sciences +11

Phosphoinositide 3-Kinase as an Upstream Regulator of the Small GTP-Binding Protein Rac in the Insulin Signaling of Membrane Ruffling

K. Kotani, Kanako Hara, K. Kotani, +2

Biochemical and Biophysical Research Communications

Upstream RegulatorSignal TransductionMolecular PhysiologyBiochemistrySignaling Pathway +10

Functional interactions of stimulatory and inhibitory GDP/GTP exchange proteins and their common substrate small GTP-binding protein.

Akira Kikuchi, Shinya Kuroda, Takuya Sasaki, +4

Journal of Biological Chemistry

Normal Activation of P70 S6 Kinase by Insulin in Cells Overexpressing Dominant Negative 85-kDa Subunit of Phosphoinositide 3-Kinase

Kenta Hara, Kazuyoshi Yonezawa, Hiroshi Sakaue, +5

Biochemical and Biophysical Research Communications

Normal ActivationSignal TransductionMolecular PhysiologyBiochemistrySignaling Pathway +10

Mosapride, a 5HT-4 receptor agonist, improves insulin sensitivity and glycaemic control in patients with Type II diabetes mellitus

Naohiko Ueno, Atsuyuki Inui, Akihiro Asakawa, +5

Diabetologia

Metabolic SyndromeInsulin SensitivityDiabetes ManagementInsulin ManagementPhysiology +10

The functional domain of the stimulatory GDP/GTP exchange protein (smg GDS) which interacts with the C-terminal geranylgeranylated region of rap1/Krev-1/smg p21.

K. Kotani, Azusa Kikuchi, Kazuya Doi, +4

PubMed