Germline Elongator mutations in Sonic Hedgehog medulloblastoma

Sebastian M. Waszak, Giles Robinson, Brian Gudenas, +59

Nature

Developmental BiologySomatic VariantDevelopmental GeneticsGeneticsMorphogenesis +4

Mitigation of acute kidney injury by cell-cycle inhibitors that suppress both CDK4/6 and OCT2 functions

Navjotsingh Pabla, Alice A. Gibson, Su Sien Ong, +10

Proceedings of the National Academy of Sciences

Hepatocellular Shuttling and Recirculation of Sorafenib-Glucuronide Is Dependent on Abcc2, Abcc3, and Oatp1a/1b

Aksana Vasilyeva, Selvi Durmuş, Lie Li, +8

Cancer Research

Sorafenib-glucuronide Is DependentGlycobiologyAnticancer Drug SorafenibHepatotoxicityMetabolism +18

Sorafenib metabolism, transport, and enterohepatic recycling: physiologically based modeling and simulation in mice

Andrea N. Edginton, Eric I. Zimmerman, Aksana Vasilyeva, +2

Cancer Chemotherapy and Pharmacology

Energy MetabolismSystems BiologyMedicineLiver PhysiologyPhysiology +12

Multikinase Inhibitors Induce Cutaneous Toxicity through OAT6-Mediated Uptake and MAP3K7-Driven Cell Death

Eric I. Zimmerman, Alice A. Gibson, Shuiying Hu, +11

Cancer Research

ApoptosisImmunologyCell DeathDermatologySorafenib Activity +14

Small molecule induction of MSH2-dependent cell death suggests a vital role of mismatch repair proteins in cell death

Aksana Vasilyeva, Jill E. Clodfelter, Brian Rector, +3

DNA repair

Genome InstabilityCell RegulationApoptosisImmunologyCell Death +5

Hypoxia-induced upregulation of BMX kinase mediates therapeutic resistance in acute myeloid leukemia

Jolieke G. van Oosterwijk, Daelynn R. Buelow, Christina D. Drenberg, +12

Journal of Clinical Investigation

Molecular classification and outcome of children with rare CNS embryonal tumors: results from St. Jude Children’s Research Hospital including the multi-center SJYC07 and SJMB03 clinical trials

Anthony P. Y. Liu, Sandeep Kumar Dhanda, Tong Lin, +34

Acta Neuropathologica

Neuro-oncologyPediatric Brain TumorsResearch HospitalPediatric NeurosurgeryPediatrics +5

Sorafenib Population Pharmacokinetics and Skin Toxicities in Children and Adolescents with Refractory/Relapsed Leukemia or Solid Tumor Malignancies

Hiroto Inaba, John C. Panetta, Stanley Pounds, +13

Clinical Cancer Research

Global effort to evacuate Ukrainian children with cancer and blood disorders who have been affected by war

Asya Agulnik, Roman Kizyma, Marta Salek, +235

The Lancet Haematology

Blood DisordersPediatric EpidemiologyGlobal EffortGlobal HealthGlobal Health Crisis +7