23:T4cb,Multifunctional hydrogel as a sealant or wound dressing with high adhesiveness and excellent antibacterial activity is highly desirable in clinical applications. In this contribution, one-step synthetic hydrogel based on quaternized chitosan (QCS), tannic acid (TA), and ferric iron (Fe(III)) is developed for skin incision closure and Staphylococcus aureus (S. aureus)-infected wound healing. In this hydrogel system, the ionic bonds and hydrogen bonds between QCS and TA form the main backbone of hydrogel, the metal coordination bonds between TA and Fe(III) (catechol-Fe) endow hydrogel with excellent adhesiveness and (near-infrared light) NIR-responsive photothermal property, and these multiple dynamic physical crosslinks enable QCS/TA/Fe hydrogel with flexible self-healing ability and injectability. Moreover, QCS/TA/Fe hydrogel possesses superior antioxidant, anti-inflammatory, hemostasis, and biocompatibility. Also, it is safe for vital organs. The data from the mouse skin incision model and infected full-thickness skin wound model presented the high wound closure effectiveness and acceleration of the wound healing process by this multifunctional hydrogel, highlighting its great potential in wound management.24:T4af,Injectable hydrogel has the advantage to fill the defective area and thereby shows promise as therapeutic implant or cell/drug delivery vehicle for tissue repair. In this study, an injectable hyaluronic acid hydrogel in situ dual-enzymatically cross-linked by galactose oxidase (GalOx) and horseradish peroxidase (HRP) was synthesized and optimized, and the therapeutic effect of this hydrogel encapsulated with bone mesenchymal stem cells (BMSC) and nerve growth factors (NGF) for traumatic brain injury (TBI) mice was investigated. Results from in vitro experiments showed that either tyramine-modified hyaluronic acid hydrogels (HT) or NGF loaded HT hydrogels (HT/NGF) possessed good biocompatibility. More importantly, the HT hydrogels loaded with BMSC and NGF could facilitate the survival and proliferation of endogenous neural cells probably by neurotrophic factors release and neuroinflammation regulation, and consequently improved the neurological function recovery and accelerated the repair process in a C57BL/6 TBI mice model. All these findings highlight that this injectable, BMSC and NGF-laden HT hydrogel has enormous potential for TBI and other tissue repair therapy.25:T4b8,Multifunctional and smart hydrogel-based hemostatic materials are of great significance in the field of medical care. In this paper, a facile method for the preparation of self-healing, adhesive and on-demand removable PBO hydrogels was established with a simple mixture of polyvinyl alcohol (PVA), borax and oligomeric procyanidin (OPC). In this hydrogel system, borax and OPC were used as dynamic crosslinkers to connect the PVA macromolecules through reversible borate ester bonds and hydrogen bonds, resulting in hydrogels that possess good self-healing and adhesive abilities. Furthermore, the PBO hydrogel displayed excellent antimicrobial activity against Escherichia coli and Staphylococcus aureus. In addition, thanks to the adhesive property of the hydrogel and the inherent hemostatic activity of OPC, this hydrogel showed rapid hemostasis performance as concluded from the in vivo experiments of mouse liver incision, tail amputation and femoral artery models. Benefitting from the fast degradation in water, this hydrogel could be easily removed on-demand within 10 min. Therefore, this well-designed PBO hydrogel offers an important prospect as a rapid hemostatic dressing.

#	Concept	H-Index	Publications	Citations
1	Biomedical Engineering	7	7	530
2	Engineering	6	6	474
3	Medicine	6	6	507
4	Social Sciences	1	1	56
5	Biomolecular Engineering	1	1	23

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