Reactive Oxygen Species Enhance Insulin Sensitivity

Kim Loh, Haiyang Deng, Atsushi Fukushima, +16

Cell Metabolism

Metabolic SyndromeBiochemistryPhysiologyDiabetesMetabolism +4

Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers

Clare G. Fedele, Lisa M. Ooms, Miriel Ho, +17

Proceedings of the National Academy of Sciences

Breast OncologyTumor BiologyInositol Polyphosphate 4-Phosphatase-iiSignaling PathwayReceptor Tyrosine Kinase +17

T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice

Florian Wiede, Benjamin J. Shields, S. Chew, +7

Journal of Clinical Investigation

Selective regulation of tumor necrosis factor–induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase

Catherine van Vliet, Patricia Bukczynska, Michelle Puryer, +4

Nature Immunology

Signal TransductionSignaling PathwayCell RegulationMedicineReceptor Tyrosine Kinase +11

TCPTP Regulates SFK and STAT3 Signaling and Is Lost in Triple-Negative Breast Cancers

Benjamin J. Shields, Florian Wiede, Esteban N. Gurzov, +10

Molecular and Cellular Biology

ImmunologyCancer BiologyTumor BiologySignaling PathwayCell Regulation +17

Requirement for Lyl1 in a model of Lmo2-driven early T-cell precursor ALL

Matthew P. McCormack, Benjamin J. Shields, Jacob T. Jackson, +6

Blood

The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1

Catherine Carmichael, Jueqiong Wang, Thao M. Nguyen, +34

Blood

Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of <i>Cdkn2a</i>

Benjamin J. Shields, Jacob T. Jackson, Donald Metcalf, +10

Genes & Development

Hhex Regulates Hematopoietic Stem Cell Self-Renewal and Stress Hematopoiesis via Repression of Cdkn2a

Jacob T. Jackson, Benjamin J. Shields, Wei Shi, +4

Stem Cells

The NUP98-HOXD13 fusion oncogene induces thymocyte self-renewal via Lmo2/Lyl1

Benjamin J. Shields, Christopher Slape, N. H. Vo, +6

Leukemia

ChromatinGenome InstabilityMedicineCell BiologyEpigenetics