Joseph DeSimone

5-Azacytidine Selectively Increases γ-Globin Synthesis in a Patient with β⁺Thalassemia

Timothy J. Ley, Joseph DeSimone, Nicholas P. Anagnou et al. · New England Journal of Medicine · 1982 · 496 citations

Medicine, Hematology, Pharmacology +9

Effects of 5-aza-2′-deoxycytidine on fetal hemoglobin levels, red cell adhesion, and hematopoietic differentiation in patients with sickle cell disease

Yogen Saunthararajah, Cheryl A. Hillery, Don Lavelle et al. · Blood · 2003 · 282 citations · Full text

Medicine, Hematology, Molecular Medicine +14

5-Azacytidine increases gamma-globin synthesis and reduces the proportion of dense cells in patients with sickle cell anemia

TJ Ley, Joseph DeSimone, CT Noguchi et al. · Blood · 1983 · 255 citations · Full text

Medicine, Biochemistry, Hematology +9

Modification of hematopoietic stem cell fate by 5aza 2′deoxycytidine and trichostatin A

Mohammed Milhem, Nadim Mahmud, Donald Lavelle et al. · Blood · 2004 · 195 citations · Full text

Life Sciences, Cell Biology, Hematology +8

2-deoxy 5-azacytidine and fetal hemoglobin induction in sickle cell anemia

Mabel Koshy, Louise Dorn, Linda R. Bressler et al. · Blood · 2000 · 174 citations

Medicine, Hematology, Molecular Medicine +9