S.L. Schreiber

Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin.

Barbara E. Bierer, Petri S. Mattila, Robert F. Standaert et al. · Proceedings of the National Academy of Sciences · 1990 · 708 citations

Life Sciences, Immunology, Pharmacology +16

Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue.

Jie Chen, Xiao-Feng Zheng, Eric J. Brown et al. · Proceedings of the National Academy of Sciences · 1995 · 569 citations

Life Sciences, Biochemistry, Molecular Biology +11

Immunosuppressants implicate protein phosphatase regulation of K+ channels in guard cells.

S Luan, W Li, Frank Rusnak et al. · Proceedings of the National Academy of Sciences · 1993 · 249 citations · Full text

Life Sciences, Plant Biology, Plant Sciences +17

Inhibition of FKBP Rotamase Activity by Immunosuppressant FK506: Twisted Amide Surrogate

MK Rosen, Masashi Nakatsuka, S.L. Schreiber · Science · 1990 · 198 citations

Medicine, Biochemistry, Pharmacology +11

FKBP-rapamycin inhibits a cyclin-dependent kinase activity and a cyclin D1-Cdk association in early G1 of an osteosarcoma cell line.

Mark W. Albers, Richard T. Williams, Eric J. Brown et al. · Journal of Biological Chemistry · 1993 · 147 citations · Full text

Life Sciences, Cell Biology, Pharmacology +15