C Paraskeva

Sodium butyrate induces apoptosis in human colonic tumour cell lines in a p53‐independent pathway: Implications for the possible role of dietary fibre in the prevention of large‐bowel cancer

Angela Hague, Anthony M. Manning, Katherine A. Hanlon et al. · International Journal of Cancer · 1993 · 535 citations

Medicine, Nutritional Sciences, Oncology +17

Induction of apoptotic cell death in human colorectal carcinoma cell lines by a cyclooxygenase-2 (COX-2)-selective nonsteroidal anti-inflammatory drug: independence from COX-2 protein expression.

Douglas J.E. Elder, Dawn E. Halton, Andrew Hague et al. · PubMed · 1997 · 369 citations

Medicine, Oncology, Pharmacology +17

VEGF165b, an antiangiogenic VEGF-A isoform, binds and inhibits bevacizumab treatment in experimental colorectal carcinoma: balance of pro- and antiangiogenic VEGF-A isoforms has implications for therapy

Alexander H. R. Varey, E S Rennel, Yan Qiu et al. · British Journal of Cancer · 2008 · 226 citations · Full text

Medicine, Oncology, Pharmacology +17

Differential sensitivity of human colonic adenoma and carcinoma cells to transforming growth factor beta (TGF-beta): conversion of an adenoma cell line to a tumorigenic phenotype is accompanied by a reduced response to the inhibitory effects of TGF-beta.

Manning Am, Ann C. Williams, Game Sm et al. · PubMed · 1991 · 172 citations

Medicine, Molecular Biology, Oncology +16

Differential growth inhibition by the aspirin metabolite salicylate in human colorectal tumor cell lines: enhanced apoptosis in carcinoma and in vitro-transformed adenoma relative to adenoma relative to adenoma cell lines.

D. J. E. Elder, Angela Hague, Daniel Hicks et al. · PubMed · 1996 · 171 citations

Medicine, Oncology, Pharmacology +16