Piero Benedetti

Expression of human DNA topoisomerase I in yeast cells lacking yeast DNA topoisomerase I: restoration of sensitivity of the cells to the antitumor drug camptothecin.

Mary‐Ann Bjornsti, Piero Benedetti, Gregory A. Viglianti et al. · PubMed · 1989 · 268 citations

Life Sciences, Microbiology, Molecular Biology +13

Inhibition of ErbB-2 Mitogenic and Transforming Activity by RALT, a Mitogen-Induced Signal Transducer Which Binds to the ErbB-2 Kinase Domain

Loredana Fiorentino, Chiara Pertica, Monia Fiorini et al. · Molecular and Cellular Biology · 2000 · 147 citations · Full text

Life Sciences, Biochemistry, Cell Biology +15

Holoenzyme assembly and ATP-mediated conformational dynamics of topoisomerase VI

Kevin D. Corbett, Piero Benedetti, James M. Berger · Nature Structural & Molecular Biology · 2007 · 104 citations

Life Sciences, Biochemistry, Molecular Biology +13

Camptothecin resistance from a single mutation changing glycine 363 of human DNA topoisomerase I to cysteine.

Piero Benedetti, P Fiorani, L Capuani et al. · PubMed · 1993 · 103 citations

Life Sciences, Genetics, Molecular Biology +9

Single Mutation in the Linker Domain Confers Protein Flexibility and Camptothecin Resistance to Human Topoisomerase I

P Fiorani, Alessandro Bruselles, Mattia Falconi et al. · Journal of Biological Chemistry · 2003 · 85 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16