Yasuhiro Itagaki

Involvement of oxidative mechanisms in blue-light-induced damage to A2E-laden RPE.

Janet R. Sparrow, Jilin Zhou, Shimon Ben‐Shabat et al. · PubMed · 2002 · 284 citations

Life Sciences, Cell Biology, Ophthalmology +17

A2E-epoxides Damage DNA in Retinal Pigment Epithelial Cells

Janet R. Sparrow, Heidi R. Vollmer-Snarr, Jilin Zhou et al. · Journal of Biological Chemistry · 2003 · 280 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14

The Biosynthesis of A2E, a Fluorophore of Aging Retina, Involves the Formation of the Precursor, A2-PE, in the Photoreceptor Outer Segment Membrane

Jianghua Liu, Yasuhiro Itagaki, Shimon Ben‐Shabat et al. · Journal of Biological Chemistry · 2000 · 246 citations · Full text

Medicine, Biochemistry, Ophthalmology +12

Biosynthetic Studies of A2E, a Major Fluorophore of Retinal Pigment Epithelial Lipofuscin

Shimon Ben‐Shabat, Craig A. Parish, Heidi R. Vollmer-Snarr et al. · Journal of Biological Chemistry · 2002 · 214 citations · Full text

Medicine, Biochemistry, Ophthalmology +15

Formation of a Nonaoxirane from A2E, a Lipofuscin Fluorophore related to Macular Degeneration, and Evidence of Singlet Oxygen Involvement This work was supported by NIH grant GM 34509 (K.N.), NSF grant NSF-CHE-98-12676 (N.J.T. and S.J.), and NIH grant EY-12951 (J.R.S.).

Shimon Ben‐Shabat, Yasuhiro Itagaki, Steffen Jockusch et al. · Angewandte Chemie International Edition · 2002 · 207 citations

Life Sciences, Cell Biology, Ophthalmology +16