Pierre‐Yves Jean‐Charles

Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9

Louis M. Luttrell, Jialu Wang, Bianca Plouffe et al. · Science Signaling · 2018 · 213 citations · Full text

Life Sciences, Genetics, Molecular Biology +14

USP20 (Ubiquitin-Specific Protease 20) Inhibits TNF (Tumor Necrosis Factor)-Triggered Smooth Muscle Cell Inflammation and Attenuates Atherosclerosis

Pierre‐Yves Jean‐Charles, Jiao‐Hui Wu, Lisheng Zhang et al. · Arteriosclerosis Thrombosis and Vascular Biology · 2018 · 54 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

Ubiquitin-specific Protease 20 Regulates the Reciprocal Functions of β-Arrestin2 in Toll-like Receptor 4-promoted Nuclear Factor κB (NFκB) Activation

Pierre‐Yves Jean‐Charles, Lisheng Zhang, Jiao‐Hui Wu et al. · Journal of Biological Chemistry · 2016 · 52 citations · Full text

Life Sciences, Immunology, Molecular Biology +15

Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling

Pierre‐Yves Jean‐Charles, Samuel Mon-Wei Yu, Dennis Abraham et al. · JCI Insight · 2017 · 42 citations · Full text

Life Sciences, Cardiology, Cell Biology +15

Dose-dependent diastolic dysfunction and early death in a mouse model with cardiac troponin mutations

Yuejin Li, Lei Zhang, Pierre‐Yves Jean‐Charles et al. · Journal of Molecular and Cellular Cardiology · 2013 · 41 citations · Full text

Life Sciences, Cardiology, Genetics +10