P.H. Kuo

Structural insights into TDP-43 in nucleic-acid binding and domain interactions

P.H. Kuo, L.G. Doudeva, Y.-T. Wang et al. · Nucleic Acids Research · 2009 · 318 citations · Full text

Life Sciences, Molecular Biology, Neuroscience +17

Full-length TDP-43 forms toxic amyloid oligomers that are present in frontotemporal lobar dementia-TDP patients

Yu-Sheng Fang, Kuen‐Jer Tsai, Yu-Jen Chang et al. · Nature Communications · 2014 · 209 citations · Full text

Medicine, Neurology, Neuroscience +16

The crystal structure of TDP-43 RRM1-DNA complex reveals the specific recognition for UG- and TG-rich nucleic acids

P.H. Kuo, Cho‐Han Chiang, Y.-T. Wang et al. · Nucleic Acids Research · 2014 · 205 citations · Full text

Life Sciences, Molecular Biology, Neuroscience +17

The Truncated C-terminal RNA Recognition Motif of TDP-43 Protein Plays a Key Role in Forming Proteinaceous Aggregates

P.H. Kuo, Chien-Hao Chiang, Jhe-Ruei Liang et al. · Journal of Biological Chemistry · 2013 · 114 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

Structural analysis of disease-related TDP-43 D169G mutation: linking enhanced stability and caspase cleavage efficiency to protein accumulation

Chien-Hao Chiang, Cédric Grauffel, Lien-Szu Wu et al. · Scientific Reports · 2016 · 99 citations · Full text

Life Sciences, Molecular Biology, Neuroscience +17