Total synthesis of human insulin by regioselective disulfide formation using the silyl chloride-sulfoxide method

Kenichi Akaji, Kenji Fujino, Tadashi Tatsumi, +1

Journal of the American Chemical Society

Pharmaceutical ScienceBioorganic ChemistryAltmetric Attention ScoreChemistryInsulin Signaling +16

Disulfide bond formation using the silyl chloride-sulfoxide system for the synthesis of a cystine peptide

Kenichi Akaji, Tadashi Tatsumi, Makoto Yoshida, +3

Journal of the American Chemical Society

EngineeringHeterocyclicBiochemistryNatural SciencesSilyl Chloride-sulfoxide System +11

Synthesis of cystine-peptide by a new disulphide bond-forming reaction using the siiyl chloride–sulphoxide system

Kenichi Akaji, Tadashi Tatsumi, Makoto Yoshida, +3

Journal of the Chemical Society Chemical Communications

Bioorganic ChemistrySiiyl Chloride–sulphoxide SystemBiochemistryReduction–oxidation ReactionMedicine +12

Regioselective double disulfide formation using silylchloride-sulfoxide system

Kenichi Akaji, Kenji Fujino, Tadashi Tatsumi, +1

Tetrahedron Letters

Silylchloride-sulfoxide SystemOrganic ChemistryChemistryDesulfurizationLayered Material

Tetrafluoroboric acid as a useful deprotecting reagent in Fmoc-based solid-phase peptide syntheses (Fmoc = fluoren-9-ylmethoxycarbonyl)

Kenichi Akaji, Makoto Yoshida, Tadashi Tatsumi, +3

Journal of the Chemical Society Chemical Communications

Bioorganic ChemistryPeptide EngineeringOrganic ChemistryPeptide SciencePeptide Therapeutics +14

Deprotection of the S-trimethylacetamidomethyl (Tacm) group using silver tetrafluoroborate: Application to the synthesis of porcine brain natriuretic peptide-32(pBNP-32).

Makoto Yoshida, Tadashi Tatsumi, Kenichi Akaji, +1

Chemical and Pharmaceutical Bulletin

Medicinal ChemistryBiochemistryNatural SciencesMedicinePeptide Library +11

Design and synthesis of inhibitors of inducible nitric oxide synthase. Discovery of a new chemical lead with potential for oral bioavailability

Yasufumi Kawanaka, Kaoru Kobayashi, Shinya Kusuda, +10

European Journal of Medicinal Chemistry

Medicinal ChemistryOral BioavailabilityNew Chemical LeadBiochemistryReactive Nitrogen Specie +7

Design and Synthesis of Orally Bioavailable Inhibitors of Inducible Nitric Oxide Synthase. Identification of 2-Azabicyclo[4.1.0]heptan-3-imines

Yasufumi Kawanaka, Kaoru Kobayashi, Shinya Kusuda, +11

Bioorganic & Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryBiochemistryReactive Nitrogen SpecieMedicine +10

Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. synthesis and biological evaluation of dihydropyridin-2(1H)-imines and 1,5,6,7-Tetrahydro-2H-azepin-2-imines

Yasufumi Kawanaka, Kaoru Kobayashi, Shinya Kusuda, +11

Bioorganic & Medicinal Chemistry

Medicinal ChemistryBiochemistryReactive Nitrogen SpecieNatural SciencesMedicine +8

Synthesis of porcine brain natriuretic peptide-32 using silver tetrafluoroborate as a new deprotecting reagent of the S-trimethylacetamidomethyl group.

Makoto Yoshida, Kenichi Akaji, Tadashi Tatsumi, +4

Chemical and Pharmaceutical Bulletin

Bioorganic ChemistryPeptide ScienceChemical BiologyMedicinal ChemistrySynthetic Pbnp-32 +15