Neonatal Fc receptor antagonist efgartigimod safely and sustainably reduces IgGs in humans

Peter Ulrichts, Antonio Guglietta, Torsten Dreier, +13

Journal of Clinical Investigation

The Role of Putative Phosphorylation Sites in the Targeting and Shuttling of the Aquaporin-2 Water Channel

Bas W. M. van Balkom, Paul J.M. Savelkoul, Daniel Markovich, +4

Journal of Biological Chemistry

Protein SecretionMolecular BiologyForskolin TreatmentCytoskeletonCellular Physiology +19

Homo-FRET Imaging Enables Quantification of Protein Cluster Sizes with Subcellular Resolution

Arjen N. Bader, Erik Hofman, Jarno Voortman, +2

Biophysical Journal

Subcellular ResolutionEngineeringProtein FoldingMedicineBioimage Analysis +8

EGF induces coalescence of different lipid rafts

Erik Hofman, Mika O. Ruonala, Arjen N. Bader, +6

Journal of Cell Science

Proteinlipid InteractionCytoskeletonLipid MovementCell GrowthCellular Physiology +14

Ligand-induced EGF Receptor Oligomerization Is Kinase-dependent and Enhances Internalization

Erik Hofman, Arjen N. Bader, Jarno Voortman, +5

Journal of Biological Chemistry

Safety, tolerability, and efficacy of subcutaneous efgartigimod in patients with chronic inflammatory demyelinating polyradiculoneuropathy (ADHERE): a multicentre, randomised-withdrawal, double-blind, placebo-controlled, phase 2 trial

Jeffrey A. Allen, Jie Lin, Ivana Basta, +23

The Lancet Neurology

OphthalmologyChronic InflammatoryMedicineSubcutaneous EfgartigimodClinical Trials +5

Imaging of protein cluster sizes by means of confocal time-gated fluorescence anisotropy microscopy

Arjen N. Bader, Erik Hofman, Paul M.P. van Bergen en Henegouwen, +1

Optics Express

Proteinlipid InteractionEngineeringMicroscopyMolecular BiologyLipid Movement +18

Efgartigimod improves muscle weakness in a mouse model for muscle-specific kinase myasthenia gravis

Maartje G. Huijbers, Jaap J. Plomp, Inge E. van Es, +7

Experimental Neurology

Muscle FunctionImmunologyMusk Myasthenia GravisCellular PhysiologyMuscle Weakness +20

Targeting chemokines and chemokine receptors with antibodies

A. Klarenbeek, David Maussang, Christophe Blanchetot, +5

Drug Discovery Today Technologies

Chemokine BiologyMedicineImmunologyPeptide TherapeuticAntibody Engineering +4

Role of cytoplasmic termini in sorting and shuttling of the aquaporin-2 water channel

Bas W. M. van Balkom, Michael P. J. Graat, M. van Raak, +3

American Journal of Physiology-Cell Physiology

Molecular BiologyWater HomeostasisCytoskeletonCellular PhysiologyCytoplasmic Termini +18