Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer

Raúl Alba, Angela C. Bradshaw, Alan L. Parker, +9

Blood

Tropism-Modification Strategies for Targeted Gene Delivery Using Adenoviral Vectors

Lynda Coughlan, Raúl Alba, Alan L. Parker, +4

Viruses

Gene TherapiesDrug TargetingTropism-modification StrategiesImmunologyClinical Gene Therapy +12

Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors

Raúl Alba, Angela C. Bradshaw, Lynda Coughlan, +13

Blood

Gene Therapy by Targeted Adenovirus-mediated Knockdown of Pulmonary Endothelial Tph1 Attenuates Hypoxia-induced Pulmonary Hypertension

Ian Morecroft, Katie White, Paola Caruso, +7

Molecular Therapy

Lung InflammationImmunologySerotonin ActsCellular PhysiologyMolecular Pharmacology +14

Structures of Adenovirus Incomplete Particles Clarify Capsid Architecture and Show Maturation Changes of Packaging Protein L1 52/55k

Gabriela N. Condezo, R. Marabini, Silvia Ayora, +4

Journal of Virology

Integrase-Deficient Lentiviral Vectors Mediate Efficient Gene Transfer to Human Vascular Smooth Muscle Cells with Minimal Genotoxic Risk

Helen Elizabeth Chick, Ali Nowrouzi, Raffaele Fronza, +8

Human Gene Therapy

Vsmc MigrationAngiogenesisMedicineMinimal Genotoxic RiskVascular Adaptation +9

Biodistribution and inflammatory profiles of novel penton and hexon double-mutant serotype 5 adenoviruses

Angela C. Bradshaw, Lynda Coughlan, Ashley M. Miller, +4

Journal of Controlled Release

Double-mutant Serotype 5ImmunologyViral PathogenesisPathologyImmune Regulation +24

Differential amplification of adenovirus vectors by flanking the packaging signal with attB/attP-ΦC31 sequences: Implications for helper-dependent adenovirus production

Raúl Alba, Patrick Hearing, Assumpció Bosch, +1

Virology

Viral ReplicationNatural SciencesPathogenesisMolecular BiologyVirology +9

Assessment of a novel, capsid-modified adenovirus with an improved vascular gene transfer profile

Katie White, Raúl Alba, Alan L. Parker, +5

Journal of Cardiothoracic Surgery

Retargeting FX-binding-ablated HAdV-5 to vascular cells by inclusion of the RGD-4C peptide in hexon hypervariable region 7 and the HI loop

Stacy Robertson, Alan L. Parker, Carolyn C. Clarke, +4

Journal of General Virology

ImmunologyImmunodominanceImmunotherapeuticsViral Structural ProteinImmune System +21