Metallothionein prolongs survival and antagonizes senescence‐associated cardiomyocyte diastolic dysfunction: role of oxidative stress

Xiaoping Yang, Thomas A. Doser, Cindy X. Fang, +15

The FASEB Journal

Heart FailureAgingLipid PeroxidationCell DeathMetallothionein Prolongs Survival +16

High-fat diet-induced juvenile obesity leads to cardiomyocyte dysfunction and upregulation of Foxo3a transcription factor independent of lipotoxicity and apoptosis

David P. Relling, Lucy B. Esberg, Cindy X. Fang, +5

Journal of Hypertension

Aging induces cardiac diastolic dysfunction, oxidative stress, accumulation of advanced glycation endproducts and protein modification

Shiyan Li, ‬Min Du, E. Kurt Dolence, +8

Aging Cell

Hypertrophic cardiomyopathy in high-fat diet-induced obesity: role of suppression of forkhead transcription factor and atrophy gene transcription

Cindy X. Fang, Feng Dong, D. Paul Thomas, +3

American Journal of Physiology-Heart and Circulatory Physiology

Metabolic DisorderGeneticsDecreased Fractional ShorteningCellular HypertrophyObesity +18

Metallothionein alleviates cardiac dysfunction in streptozotocin-induced diabetes: Role of Ca2+ cycling proteins, NADPH oxidase, poly(ADP-Ribose) polymerase and myosin heavy chain isozyme

Loren E. Wold, Asli F. Ceylan‐Isik, Cindy X. Fang, +5

Free Radical Biology and Medicine

Metabolic SyndromeCa2+ Cycling ProteinsHeart FailureCardiomyopathyCardiovascular Disease +11

A newly synthetic chromium complex – chromium(phenylalanine)₃ improves insulin responsiveness and reduces whole body glucose tolerance

Xiaoping Yang, Kamalakannan Palanichamy, Allyn C. Ontko, +4

FEBS Letters

Cardiac overexpression of catalase rescues cardiac contractile dysfunction induced by insulin resistance: role of oxidative stress, protein carbonyl formation and insulin sensitivity

Feng Dong, Cindy X. Fang, Xiaoping Yang, +3

Diabetologia

Insulin ResistanceMetabolic SyndromeCardiomyopathyCardiac MuscleInsulin Signaling +11

Maternal nutrient restriction during early to mid gestation up-regulates cardiac insulin-like growth factor (IGF) receptors associated with enlarged ventricular size in fetal sheep

Feng Dong, Stephen P. Ford, Cindy X. Fang, +3

Growth Hormone & IGF Research

Animal PhysiologyPregnancy NutritionDevelopmental BiologyGrowth HormoneMedicine +11

Metallothionein alleviates cardiac contractile dysfunction induced by insulin resistance: role of Akt phosphorylation, PTB1B, PPARγ and c-Jun

Cindy X. Fang, Feng Dong, Bonnie H. Ren, +2

Diabetologia

Insulin ResistanceMolecular PharmacologyInsulin SignalingMolecular PhysiologyHealth Sciences +12

Metallothionein antagonizes aging‐induced cardiac contractile dysfunction: role of PTP1B, insulin receptor tyrosine phosphorylation and Akt

Cindy X. Fang, Thomas A. Doser, Xiaoping Yang, +2

Aging Cell