Prevention and reversal of cardiac hypertrophy by soluble epoxide hydrolase inhibitors

Danyan Xu, Ning Li, Yuxia He, +11

Proceedings of the National Academy of Sciences

Soluble Epoxide Hydrolase: A Novel Therapeutic Target in Stroke

Wenri Zhang, Ines P. Koerner, Ruediger Noppens, +7

Journal of Cerebral Blood Flow & Metabolism

Lipid PeroxidationPharmacotherapyCerebral Vascular RegulationOxidative StressSoluble Epoxide Hydrolase +15

Soluble epoxide hydrolase deficiency alters pancreatic islet size and improves glucose homeostasis in a model of insulin resistance

A. R. Luria, Ahmed Bettaieb, Yannan Xi, +7

Proceedings of the National Academy of Sciences

Soluble Epoxide Hydrolase Inhibitors Reduce the Development of Atherosclerosis in Apolipoprotein E-Knockout Mouse Model

Arzu Ulu, Benjamin B. Davis, Hsing-Ju Tsai, +6

Journal of Cardiovascular Pharmacology

Vascular DiseaseHyperlipidemiaOxidative StressInflammationMetabolic Syndrome +16

Soluble Epoxide Inhibition Is Protective Against Cerebral Ischemia via Vascular and Neural Protection

Alexis N. Simpkins, R. Daniel Rudic, Derek A. Schreihofer, +5

American Journal Of Pathology

Social SciencesCerebral Vascular RegulationNeurovascular DiseaseOxidative StressBrain Injury +14

Optimization of Amide-Based Inhibitors of Soluble Epoxide Hydrolase with Improved Water Solubility

In-Hae Kim, Fenton R. Heirtzler, Christophe Morisseau, +3

Journal of Medicinal Chemistry

Experimental PharmacologyEnzymatic ModificationRedox BiologyPharmaceutical ChemistryOxidative Stress +16

Synthesis and SAR of conformationally restricted inhibitors of soluble epoxide hydrolase

Paul D. Jones, Hsing-Ju Tsai, N. Zung, +2

Bioorganic & Medicinal Chemistry Letters

Soluble Epoxide HydrolaseMedicinal ChemistryBiochemistryNatural SciencesBiocatalysis +8

Pharmacokinetic screening of soluble epoxide hydrolase inhibitors in dogs

Hsing-Ju Tsai, Sung Hee Hwang, Christophe Morisseau, +5

European Journal of Pharmaceutical Sciences

MedicinePharmacotherapyPharmacokinetic ScreeningPharmacologyPharmacokinetics +1

1,3-Disubstituted Ureas Functionalized with Ether Groups are Potent Inhibitors of the Soluble Epoxide Hydrolase with Improved Pharmacokinetic Properties

In-Hae Kim, Hsing-Ju Tsai, Kosuke Nishi, +3

Journal of Medicinal Chemistry

PharmacotherapyPharmaceutical ChemistryPhysical PropertiesOxidative StressSoluble Epoxide Hydrolase +16

Opposite Regulation of Cholesterol Levels by the Phosphatase and Hydrolase Domains of Soluble Epoxide Hydrolase

Ahmed Enayetallah, A. R. Luria, BeiBei Luo, +4

Journal of Biological Chemistry

Lipid PeroxidationRedox BiologyOxidative StressInflammationMetabolic Syndrome +19