Immunomodulatory activity of curcumin: suppression of lymphocyte proliferation, development of cell-mediated cytotoxicity, and cytokine production in vitro

Xiaohua Gao, Jarret Kuo, Hao Jiang, +6

Biochemical Pharmacology

InflammationAnti-inflammatoryMedicineImmune RegulationImmunology +7

Curcumin (diferuloyl-methane) enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in LNCaP prostate cancer cells.

Dorrah Deeb, Yong Xu, Hao Jiang, +4

PubMed

Anti-inflammatoryChemoprevention StrategyMedicineNutraceutical IngredientApoptosis +11

Curcumin sensitizes prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L by inhibiting nuclear factor-kappaB through suppression of IkappaBalpha phosphorylation.

Dorrah Deeb, Hao Jiang, Xiaohua Gao, +6

PubMed

Chemoprevention StrategyMedicineApoptosisPharmacologyIkappabalpha Phosphorylation +11

Curcumin sensitizes prostate cancer cells to tumor necrosis factor–related apoptosis-inducing ligand/Apo2L by inhibiting nuclear factor-κB through suppression of IκBα phosphorylation

Dorrah Deeb, Hao Jiang, Xiaohua Gao, +6

Molecular Cancer Therapeutics

Chemoprevention StrategyApoptosisImmunologyPathologyCell Death +16

Curcumin [1,7-Bis(4-hydroxy-3-methoxyphenyl)-1–6-heptadine-3,5-dione; C21H20O6] Sensitizes Human Prostate Cancer Cells to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand/Apo2L-Induced Apoptosis by Suppressing Nuclear Factor-κB via Inhibition of the Prosurvival Akt Signaling Pathway

Dorrah Deeb, Hao Jiang, Xiaohua Gao, +4

Journal of Pharmacology and Experimental Therapeutics

Oleanane triterpenoid CDDO-Me inhibits growth and induces apoptosis in prostate cancer cells through a ROS-dependent mechanism

Dorrah Deeb, Xiaohua Gao, Hao Jiang, +5

Biochemical Pharmacology

MedicineCell DeathProstate Cancer CellsRos-dependent MechanismAnti-cancer Agent +6

Synthetic triterpenoids inhibit growth and induce apoptosis in human glioblastoma and neuroblastoma cells through inhibition of prosurvival Akt, NF-κB and Notch1 signaling

Xiaohua Gao, Dorrah Deeb, Hao Jiang, +3

Journal of Neuro-Oncology

Prosurvival AktGliomaMedicineApoptosisCancer Cell Biology +8

Growth inhibitory and apoptosis-inducing effects of xanthohumol, a prenylated chalone present in hops, in human prostate cancer cells.

Dorrah Deeb, Xiaohua Gao, Hao Jiang, +3

PubMed

UrologyMedicineApoptosisPrenylated Chalone PresentMitochondrial Depolarization +13

Curcumin differentially sensitizes malignant glioma cells to TRAIL/Apo2L-mediated apoptosis through activation of procaspases and release of cytochrome c from mitochondria.

Xiaohua Gao, Dorrah Deeb, Hao Jiang, +3

PubMed

Trail/apo2l-mediated ApoptosisChemoprevention StrategyApoptosisCell DeathPathology +18

Immunomodulatory activity of resveratrol: discrepant in vitro and in vivo immunological effects

Xiaohua Gao, Dorrah Deeb, Joseph Media, +4

Biochemical Pharmacology

InflammationAutoimmune DiseaseImmunotoxicologyMedicineVivo Immunological Effects +6