R M Shepherd

Oscillations of secretion driven by oscillations of cytoplasmic Ca2+ as evidences in single pancreatic islets.

Patrick Gilon, R M Shepherd, J. C. Henquin · Journal of Biological Chemistry · 1993 · 323 citations · Full text

Insulin Oscillations, Homeostatic Mechanism, Ca2+i Oscillations +21

Glucose modulation of insulin mRNA levels is dependent on transcription factor PDX-1 and occurs independently of changes in intracellular Ca2+.

Wendy M. Macfarlane, R M Shepherd, Karen E. Cosgrove et al. · Diabetes · 2000 · 68 citations · Full text

Glucose Modulation, Insulin Signaling, Insulin Production +16

Hyperinsulinism of Infancy: The Regulated Release of Insulin by KATP Channel--Independent Pathways

Susanne G. Straub, Karen E. Cosgrove, Carina Ämmälä et al. · Diabetes · 2001 · 67 citations

Cellular Physiology, Insulin Signaling, Hyperpolarization (Biology) +20

ATP-sensitive potassium channels and efaroxan-induced insulin release in the electrofusion-derived BRIN-BD11 beta-cell line.

JC Chapman, Neville H. McClenaghan, Karen E. Cosgrove et al. · Diabetes · 1999 · 30 citations

Patch-clamp Techniques, Efaroxan-induced Insulin Release, Cellular Physiology +18

Ketoisocaproic acid and leucine increase cytoplasmic pH in mouse pancreatic B cells: role of cytoplasmic Ca2+ and pH-regulating exchangers.

R M Shepherd, Patrick Gilon, J. C. Henquin · Endocrinology · 1996 · 12 citations

Pancreas Transplantation, Cellular Physiology, Insulin Signaling +22