Melvin S. Center

ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein.

Gabriele Jedlitschky, Inka Leier, Ulrike Buchholz et al. · PubMed · 1994 · 437 citations

Proteinlipid Interaction, Signal Transduction, Biochemistry +12

The MRP gene associated with a non-P-glycoprotein multidrug resistance encodes a 190-kDa membrane bound glycoprotein.

Melvin S. Center · PubMed · 1993 · 296 citations

Non-p-glycoprotein Multidrug Resistance, Protein Function, Biochemistry +13

Mechanisms of multidrug resistance in HL60 cells: detection of resistance-associated proteins with antibodies against synthetic peptides that correspond to the deduced sequence of P-glycoprotein.

D Marquardt, Sue McCrone, Melvin S. Center · PubMed · 1990 · 117 citations

Mr 180,000, Resistance-associated Proteins, Immunology +17

Mechanisms of multidrug resistance in HL60 cells: evidence that a surface membrane protein distinct from P-glycoprotein contributes to reduced cellular accumulation of drug.

Tim McGrath, Melvin S. Center · PubMed · 1988 · 117 citations

Proteinlipid Interaction, P-glycoprotein Contributes, Cellular Pharmacology +20

Drug transport mechanisms in HL60 cells isolated for resistance to adriamycin: evidence for nuclear drug accumulation and redistribution in resistant cells.

D Marquardt, Melvin S. Center · PubMed · 1992 · 93 citations

Cellular Pharmacology, Drug Transport Mechanisms, Daunomycin Distribution +16