Orai1 and STIM1 Are Critical for Breast Tumor Cell Migration and Metastasis

Shengyu Yang, J. Jillian Zhang, Xin-Yun Huang

Cancer Cell

Breast OncologyStim1 Are CriticalMedicineBreast CancerRadiation Oncology +3

Structural Basis for Relief of Autoinhibition of the Dbl Homology Domain of Proto-Oncogene Vav by Tyrosine Phosphorylation

Behzad Aghazadeh, William E. Lowry, Xin-Yun Huang, +1

Cell

Tyrosine PhosphorylationProtein FunctionSignal TransductionMolecular BiologyStructural Basis +5

Tyrosine kinases in activation of the MAP kinase cascade by G-protein-coupled receptors

Yong Wan, Tomohiro Kurosaki, Xin-Yun Huang

Nature

Molecular PhysiologySignal TransductionSignaling PathwayMap Kinase CascadeMedicine +9

Migrastatin analogues target fascin to block tumour metastasis

Lin Chen, Shengyu Yang, Jean Jakoncic, +2

Nature

MedicineAnti-cancer AgentCancer TreatmentMigrastatin AnaloguesPharmacology +1

Direct stimulation of Bruton's tyrosine kinase by Gq-protein α-subunit

Kendra K. Bence, Wei Ma, Tohru Kozasa, +1

Nature

Molecular PharmacologySignal TransductionMolecular PhysiologyG Protein-coupled ReceptorReceptor Tyrosine Kinase +7

The G protein Gα12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain

Yun Jiang, Wei Ma, Yong Wan, +3

Nature

Conserved Ph/bm DomainSignal TransductionMolecular PhysiologyCell RegulationMolecular Regulation +10

The Migrastatin Family:  Discovery of Potent Cell Migration Inhibitors by Chemical Synthesis

Christoph Gaul, Jón T. Njardarson, Dandan Shan, +6

Journal of the American Chemical Society

Discovery of Potent Cell Migration Inhibitors through Total Synthesis:  Lessons from Structure−Activity Studies of (+)-Migrastatin

Jón T. Njardarson, Christoph Gaul, Dandan Shan, +2

Journal of the American Chemical Society

Concise Total SynthesisCombinatorial ChemistryMedicinal ChemistryNatural Product SynthesisBiochemistry +9

Synthetic analogues of migrastatin that inhibit mammary tumor metastasis in mice

Dandan Shan, Lin Chen, Jón T. Njardarson, +4

Proceedings of the National Academy of Sciences

PharmacotherapyCancer BiologyTumor BiologyMedicinal ChemistryAnti-cancer Agent +14

Molecular Mechanism of Fascin Function in Filopodial Formation

Shengyu Yang, Fang-Ke Huang, Jianyun Huang, +7

Journal of Biological Chemistry