DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction

Ann-Marie E Bröske, Lena Vockentanz, Shabnam Kharazi, +12

Nature Genetics

ChromatinMedicineGeneticsDna MethylationEpigenetic Change +8

Molecular Evidence for Hierarchical Transcriptional Lineage Priming in Fetal and Adult Stem Cells and Multipotent Progenitors

Robert Månsson, Anne Hultquist, Sidinh Luc, +13

Immunity

Multipotent ProgenitorsEmbryonic Stem CellCell LineageLineage PlasticityDevelopmental Biology +10

Lymphomyeloid Contribution of an Immune-Restricted Progenitor Emerging Prior to Definitive Hematopoietic Stem Cells

Charlotta Böiers, Joana Carrelha, Michael Lutteropp, +23

Cell stem cell

Bone Marrow FailureStem Cell MobilizationImmunologyHematologyPathology +9

Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth

Kashyap Dave, Inderpreet Sur, Jian Yan, +10

eLife

FLT3 ligand and not TSLP is the key regulator of IL-7–independent B-1 and B-2 B lymphopoiesis

Christina T. Jensen, Shabnam Kharazi, Charlotta Böiers, +4

Blood

Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model

Burcu Bestas, Pedro M. D. Moreno, K. Emelie M. Blomberg, +16

Journal of Clinical Investigation

Btk MrnaKnockout MouseNovel TherapyNatural SciencesTyrosine Kinase +13

Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD–induced myeloproliferation

Adam J. Mead, Wen Hao Neo, Nikolaos Barkas, +19

The Journal of Experimental Medicine

FLT3-ITDs Instruct a Myeloid Differentiation and Transformation Bias in Lymphomyeloid Multipotent Progenitors

Adam J. Mead, Shabnam Kharazi, Deborah Atkinson, +16

Cell Reports

Hematological MalignancyMyeloid DifferentiationCell DivisionMixed-phenotype Acute LeukemiaGenetics +7

Expression and role of FLT3 in regulation of the earliest stage of normal granulocyte-monocyte progenitor development

Charlotta Böiers, Natalija Buza-Vidas, Christina T. Jensen, +6

Blood

Down-regulation of Mpl marks the transition to lymphoid-primed multipotent progenitors with gradual loss of granulocyte-monocyte potential

Sidinh Luc, Kristina Anderson, Shabnam Kharazi, +6

Blood