A Murine Model in Which Protection Correlates with Pertussis Vaccine Efficacy in Children Reveals Complementary Roles for Humoral and Cell-Mediated Immunity in Protection against<i>Bordetella pertussis</i>

Kingston H. G. Mills, Mark Ryan, Elizabeth J. Ryan, +1

Infection and Immunity

Activation of natural killer T cells by α-galactosylceramide in the presence of CD1d provides protection against colitis in mice

Lawrence J. Saubermann, Paul L. Beck, Ype P. de Jong, +14

Gastroenterology

InflammationAllergyMucosal ImmunologyAdaptive Immune SystemImmune Regulation +11

<i>Bordatella pertussis</i>Respiratory Infection in Children Is Associated with Preferential Activation of Type 1 T Helper Cells

Mark Ryan, Geraldine A. Murphy, Leif Gothefors, +3

The Journal of Infectious Diseases

Pertussis toxin potentiates Th1 and Th2 responses to co-injected antigen: adjuvant action is associated with enhanced regulatory cytokine production and expression of the co-stimulatory molecules B7- 1, B7-2 and CD28

Mark Ryan

International Immunology

Adaptive Immune SystemImmune RegulationImmunologyImmunodominanceAdjuvant Action +17

CCR8 Expression Identifies CD4 Memory T Cells Enriched for FOXP3+ Regulatory and Th2 Effector Lymphocytes

Dulce Soler, Tobias R. Chapman, Louis Poisson, +9

The Journal of Immunology

Foxp3+ RegulatoryT-regulatory CellImmunologyImmune RegulationRegulatory T Cells +17

IL-21 Receptor Is Required for the Systemic Accumulation of Activated B and T Lymphocytes in MRL/MpJ-Fas<i>lpr/lpr</i>/J Mice

Andrew L. Rankin, Heath Guay, Deborah Herber, +14

The Journal of Immunology

ImmunologyImmune RegulationIl-21-dependent MannerImmunologic MechanismCd4 T Cell Responses +19

Delineation of a CD1d-restricted antigen presentation pathway associated with human and mouse intestinal epithelial cells

Yvonne van de Wal, Nadia Corazza, Matthieu Allez, +9

Gastroenterology

Cd1d-restricted Antigen PresentationAutoimmune DiseaseMucosal ImmunologyImmunologyImmune Regulation +5

Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues and increased susceptibility to LPS-induced lethality

Erica Marchlik, Paresh Thakker, Thaddeus Carlson, +15

Journal of Leukocyte Biology

Innate Immune SystemImmune RegulationImmunologyMutant Tbk1 AlleleImmunologic Mechanism +21

Serine Protease HTRA1 Antagonizes Transforming Growth Factor-β Signaling by Cleaving Its Receptors and Loss of HTRA1 In Vivo Enhances Bone Formation

Julie R. Graham, Angela Chamberland, Qingcong Lin, +7

PLoS ONE

Human GrowthImmune RegulationBone RepairSerine ProteasesType Ii +14

Bordetella pertussis-specific Th1/Th2 cells generated following respiratory infection or immunization with an acellular vaccine: comparison of the T cell cytokine profiles in infants and mice.

Mark Ryan, Leif Gothefors, Kingston H. G. Mills

PubMed

B. Pertussis InfectionAdaptive Immune SystemHumoral ResponseImmunologyImmunologic Mechanism +14