Active site remodelling accompanies thioester bond formation in the SUMO E1

Shaun K. Olsen, Allan D. Capili, Xuequan Lu, +2

Nature

BiochemistryProtein AssemblyProtein FoldingNatural SciencesActive Site +6

FTY720 Inhibits Ceramide Synthases and Up-regulates Dihydrosphingosine 1-Phosphate Formation in Human Lung Endothelial Cells

Evgeny Berdyshev, Anastasia Skobeleva, Robert Bittman, +5

Journal of Biological Chemistry

Ceramide Synthesis Is Modulated by the Sphingosine Analog FTY720 via a Mixture of Uncompetitive and Noncompetitive Inhibition in an Acyl-CoA Chain Length-de pend ent Manner

Sujoy Lahiri, Hye Jung Park, Elad L. Laviad, +3

Journal of Biological Chemistry

FTY720 Analogues as Sphingosine Kinase 1 Inhibitors

Keng G. Lim, Francesca Tonelli, Zaiguo Li, +4

Journal of Biological Chemistry

Molecular BiologyPharmacotherapyChemical BiologySk1 ContingentSphingosine Kinase 1 +16

Mycobacterial Phenolic Glycolipid Virulence Factor Biosynthesis: Mechanism and Small-Molecule Inhibition of Polyketide Chain Initiation

Julián A. Ferreras, Karen Stirrett, Xuequan Lu, +4

Chemistry & Biology

BiosynthesisVirulence FactorBacteriologyGlycobiologyMolecular Biology +6

Designed Semisynthetic Protein Inhibitors of Ub/Ubl E1 Activating Enzymes

Xuequan Lu, Shaun K. Olsen, Allan D. Capili, +3

Journal of the American Chemical Society

Mechanism-based inhibitors of MenE, an acyl-CoA synthetase involved in bacterial menaquinone biosynthesis

Xuequan Lu, Huaning Zhang, Peter J. Tonge, +1

Bioorganic & Medicinal Chemistry Letters

BiosynthesisBiotransformationBiochemistryBacterial Menaquinone BiosynthesisMechanism-based Inhibitors +6

Structural basis for adenylation and thioester bond formation in the ubiquitin E1

Z.S. Hann, Cheng Ji, Shaun K. Olsen, +4

Proceedings of the National Academy of Sciences

Synthesis and Evaluation of an α‐<i>C</i>‐Galactosylceramide Analogue that Induces Th1‐biased Responses in Human Natural Killer T Cells

Xuequan Lu, Liping Song, Leonid S. Metelitsa, +1

ChemBioChem

Medicinal ChemistryCancer ImmunosurveillanceMedicineNatural Killer TImmunology +13

Stable Analogues of OSB‐AMP: Potent Inhibitors of MenE, the <i>o</i>‐Succinylbenzoate‐CoA Synthetase from Bacterial Menaquinone Biosynthesis

Xuequan Lu, Rong Zhou, Indrajeet Sharma, +5

ChemBioChem