Ventricular Assist Device Implantation Corrects Myocardial Lipotoxicity, Reverses Insulin Resistance, and Normalizes Cardiac Metabolism in Patients With Advanced Heart Failure

Aalap Chokshi, Konstantinos Drosatos, Faisal H. Cheema, +14

Circulation

Peroxisome Proliferator–Activated Receptor-γ Activation Prevents Sepsis-Related Cardiac Dysfunction and Mortality In Mice

Konstantinos Drosatos, Raffay Khan, Chad M. Trent, +6

Circulation Heart Failure

Delivery of Nox2-NADPH oxidase siRNA with polyketal nanoparticles for improving cardiac function following myocardial infarction

Inthirai Somasuntharam, Archana V. Boopathy, Raffay Khan, +4

Biomaterials

NanomedicinePolyketal NanoparticlesNox2-nadph Oxidase SirnaEngineeringTherapeutic Nanomaterials +7

Adipose Tissue Inflammation and Adiponectin Resistance in Patients With Advanced Heart Failure

Raffay Khan, Tomoko S. Kato, Aalap Chokshi, +13

Circulation Heart Failure

Inhibition of c-Jun-N-terminal Kinase Increases Cardiac Peroxisome Proliferator-activated Receptor α Expression and Fatty Acid Oxidation and Prevents Lipopolysaccharide-induced Heart Dysfunction

Konstantinos Drosatos, Zoi Drosatos-Tampakaki, Raffay Khan, +4

Journal of Biological Chemistry

Heart FailureJnk InhibitionLipid PeroxidationCardiovascular PharmacologyMetabolic Remodeling +17

Cardiomyocyte Specific Deficiency of Serine Palmitoyltransferase Subunit 2 Reduces Ceramide but Leads to Cardiac Dysfunction

Su‐Yeon Lee, Jung Ran Kim, Yunying Hu, +12

Journal of Biological Chemistry

Cardiac MuscleCardiomyopathyHeart FailureMolecular PhysiologyCardiomyocyte Specific Deficiency +9

DGAT1 deficiency decreases PPAR expression and does not lead to lipotoxicity in cardiac and skeletal muscle

Li Liu, Shuiqing Yu, Raffay Khan, +11

Journal of Lipid Research

Cardiomyocyte lipids impair β-adrenergic receptor function via PKC activation

Konstantinos Drosatos, Kalyani G. Bharadwaj, Anastasios Lymperopoulos, +10

American Journal of Physiology-Endocrinology and Metabolism

Normal HeartsMolecular PharmacologyMolecular PhysiologyCardiovascular DiseaseBiochemistry +12

Analysis of mouse models of cytochrome c oxidase deficiency owing to mutations in Sco2

Hua Yang, Sonja Brosel, Rebeca Acín‐Pérez, +7

Human Molecular Genetics

Mice With Cardiac Overexpression of Peroxisome Proliferator–Activated Receptor γ Have Impaired Repolarization and Spontaneous Fatal Ventricular Arrhythmias

John Morrow, Alexander N. Katchman, Ni-Huiping Son, +12

Circulation