Loss of TRIM21 alleviates cardiotoxicity by suppressing ferroptosis induced by the chemotherapeutic agent doxorubicin

Kai Hou, Jianliang Shen, Junrong Yan, +10

EBioMedicine

The Ubiquitin E3 Ligase TRIM21 Promotes Hepatocarcinogenesis by Suppressing the p62-Keap1-Nrf2 Antioxidant Pathway

Fang Wang, Ye Zhang, Jianliang Shen, +19

Cellular and Molecular Gastroenterology and Hepatology

TRIM21 ubiquitylates GPX4 and promotes ferroptosis to aggravate ischemia/reperfusion-induced acute kidney injury

Xiaolin Sun, Ning Huang, Peng Li, +6

Life Sciences

UrologyRenal FunctionIron MetabolismKidney FailureRenal Inflammation +6

NCOA5 Haploinsufficiency Results in Glucose Intolerance and Subsequent Hepatocellular Carcinoma

Shenglan Gao, Aimin Li, Feiye Liu, +7

Cancer Cell

HepatologyLiver PhysiologyPathologyGlucose IntoleranceHepatotoxicity +8

Glutamine synthetase limits β-catenin–mutated liver cancer growth by maintaining nitrogen homeostasis and suppressing mTORC1

Weiwei Dai, Jianliang Shen, Junrong Yan, +13

Journal of Clinical Investigation

Radiation OncologyGs AblationGenetic AblationOncogenic AgentMedicine +12

BDNF-TrkB Pathway Mediates Neuroprotection of Hydrogen Sulfide against Formaldehyde-Induced Toxicity to PC12 Cells

Jiamei Jiang, Chengfang Zhou, Shenglan Gao, +5

PLoS ONE

Cell DeathRedox BiologyToxicological MechanismFormaldehyde-induced ToxicityOxidative Stress +17

TIP30 loss enhances cytoplasmic and nuclear EGFR signaling and promotes lung adenocarcinogenesis in mice

Aimin Li, Chengliang Zhang, Shenglan Gao, +4

Oncogene

Cancer ResearchDevelopmental BiologyMedicineBronchial NeoplasmNuclear Egfr Signaling +8

Activation of polyamine catabolism promotes glutamine metabolism and creates a targetable vulnerability in lung cancer

Xinlu Han, Deyu Wang, Yang Liao, +8

Proceedings of the National Academy of Sciences

Tumor BiologyGlutamine MetabolismBiochemistryOncogenic AgentMedicine +12

MiR‐5100 increases the cisplatin resistance of the lung cancer stem cells by inhibiting the Rab6

Lawei Yang, Ziying Lin, Yahong Wang, +8

Molecular Carcinogenesis

The TIP30 Protein Complex, Arachidonic Acid and Coenzyme A Are Required for Vesicle Membrane Fusion

Chengliang Zhang, Aimin Li, Shenglan Gao, +2

PLoS ONE