P. J. M. Guelen

Decreased plasma albumin concentration results in increased volume of distribution and decreased elimination of midazolam in intensive care patients

Tom B. Vree, Minoru Shimoda, Jacques J. Driessen et al. · Clinical Pharmacology & Therapeutics · 1989 · 112 citations

Pharmacotherapy, Nephrology, Increased Volume +19

The effects of acute changes in renal function on the pharmacokinetics of midazolam during long-term infusion in ICU patients.

J. J. Driessen, T.B. Vree, P. J. M. Guelen · PubMed · 1991 · 68 citations

Infusion Rate, Plasma Elimination Half-life, Renal Function +13

Pharmacokinetics of rectal diclofenac and its hydroxy metabolites in man.

D. Landsdorp, T. B. Vree, P. J. M. Guelen · PubMed · 1990 · 47 citations

Medicinal Chemistry, Pharmaceutical Science, Pharmacological Study +15

High-performance liquid chromatographic method for the determination of diclofenac and its hydroxy metabolites in human plasma and urine

D. Lansdorp, P. J. M. Guelen, T. B. Vree · Journal of Chromatography B Biomedical Sciences and Applications · 1990 · 46 citations

Gas Chromatography, Medicine, Bioanalysis +12

Pharmacokinetics of naproxen, its metabolite <i>O</i>‐desmethylnaproxen, and their acyl glucuronides in humans

Tom B. Vree, M. van den Biggelaar-Martea, C.P.W.G.M. Verwey-van Wissen et al. · Biopharmaceutics & Drug Disposition · 1993 · 46 citations