Molecular modeling of flavonoids that inhibits xanthine oxidase

Chun‐Mao Lin, Chien-Shu Chen, Chien-Tsu Chen, +2

Biochemical and Biophysical Research Communications

BiochemistryMedicinePhytochemicalPhytochemistryPharmacology +3

Structure–activity relationship of coumarin derivatives on xanthine oxidase-inhibiting and free radical-scavenging activities

Hsiu‐Chen Lin, Shin-Hui Tsai, Chien-Shu Chen, +4

Biochemical Pharmacology

Structure–activity RelationshipBiochemistryFree Radical-scavenging ActivitiesMedicineRadical (Chemistry) +5

Nucleosides: XI. Synthesis and Antiviral Evaluation of 5'-Alkylthio-5'-deoxy Quinazolinone Nucleoside Derivatives as S-Adenosyl-L-homocysteine Analogs

Tun‐Cheng Chien, Chien-Shu Chen, Fang-Hwa Yu, +1

Chemical and Pharmaceutical Bulletin

Constituents from the Formosan apple reduce tyrosinase activity in human epidermal melanocytes

Yi-Pei Lin, Feng‐Lin Hsu, Chien-Shu Chen, +2

Phytochemistry

Tyrosinase ActivityBiochemistryCutaneous BiologyMelanomaDermatology +4

Structure-Based Discovery of Triphenylmethane Derivatives as Inhibitors of Hepatitis C Virus Helicase

Chien-Shu Chen, Chun-Tang Chiou, Grace Shiahuy Chen, +9

Journal of Medicinal Chemistry

Structure-activity relationship of C6-C3 phenylpropanoids on xanthine oxidase-inhibiting and free radical-scavenging activities

Yuan-Ching Chang, Fu-Wei Lee, Chien-Shu Chen, +4

Free Radical Biology and Medicine

BiochemistryFree Radical-scavenging ActivitiesMedicineNatural SciencesRadical (Chemistry) +8

Discovery of Akt Kinase Inhibitors through Structure-Based Virtual Screening and Their Evaluation as Potential Anticancer Agents

Chih‐Hung Chuang, Ta-Chun Cheng, Yu-Ling Leu, +3

International Journal of Molecular Sciences

Drug TargetHit IdentificationChemoprevention StrategyAkt KinaseTumor Biology +20

Phytochemicals from Acacia confusa Heartwood Extracts Reduce Serum Uric Acid Levels in Oxonate-Induced Mice: Their Potential Use as Xanthine Oxidase Inhibitors

Yu‐Tang Tung, Chih-An Hsu, Chien-Shu Chen, +3

Journal of Agricultural and Food Chemistry

Hydrophilic Ester-Bearing Chlorogenic Acid Binds to a Novel Domain to Inhibit Xanthine Oxidase

Shwu-Huey Wang, Chien-Shu Chen, Shih‐Hao Huang, +4

Planta Medica

OxysterolBiochemistryInhibit Xanthine OxidaseMedicineNatural Sciences +13

Targeting of Topoisomerase I for Prognoses and Therapeutics of Camptothecin-Resistant Ovarian Cancer

Yu-Chieh Lee, Chii-Hong Lee, Hsiang-Ping Tsai, +10

PLoS ONE

Top1 InhibitorsOncologyCamptothecin-resistant Ovarian CancerMedicineDna Topoisomerase +10