Antimalarial efficacy of MMV390048, an inhibitor of <i>Plasmodium</i> phosphatidylinositol 4-kinase

Tanya Paquet, Claire Le Manach, Diego González Cabrera, +49

Science Translational Medicine

Crystal Structure of Human MMP9 in Complex with a Reverse Hydroxamate Inhibitor

Siân Rowsell, Paul Hawtin, Claire A. Minshull, +8

Journal of Molecular Biology

Crystal StructureHuman Mmp9MedicineNatural SciencesMetalloprotein +7

(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of <i>Plasmodium</i>

Marı́a Belén Jiménez-Dı́az, Daniel Ebert, Yandira G. Salinas, +46

Proceedings of the National Academy of Sciences

Phenotypic ScreeningAntiparasitic AgentMalariaImmunologyMolecular Biology +15

UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria

Christel Brunschwig, Nina Lawrence, Dale Taylor, +45

Antimicrobial Agents and Chemotherapy

3,5-Diaryl-2-aminopyridines as a Novel Class of Orally Active Antimalarials Demonstrating Single Dose Cure in Mice and Clinical Candidate Potential

Yassir Younis, Frédèric Douelle, Tzu‐Shean Feng, +20

Journal of Medicinal Chemistry

Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy

Beatriz Baragaña, Neil R. Norcross, Caroline Wilson, +24

Journal of Medicinal Chemistry

A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria

Margaret A. Phillips, Karen L. White, Sreekanth Kokkonda, +33

ACS Infectious Diseases

Methoxytetrahydropyrans. A new series of selective and orally potent 5-lipoxygenase inhibitors

G. C. CRAWLEY, Robert I. Dowell, Philip N. Edwards, +5

Journal of Medicinal Chemistry

Pharmaceutical SciencePharmacotherapyNew SeriesPharmaceutical ChemistryDrug Resistance +14

Novel Orally Active Antimalarial Thiazoles

Diego González Cabrera, Frédèric Douelle, Tzu‐Shean Feng, +11

Journal of Medicinal Chemistry

Antiparasitic AgentMalariaCellular PharmacologyPharmacokineticsPre-clinical Pharmacology +16

Synthesis and structure–activity relationships of novel benzoxaboroles as a new class of antimalarial agents

Yong-Kang Zhang, Jacob J. Plattner, Yvonne R. Freund, +14

Bioorganic & Medicinal Chemistry Letters

Novel BenzoxaborolesAntiparasitic AgentMedicineNew ClassChemistry +4