Glycopeptide enkephalin analogues produce analgesia in mice: evidence for penetration of the blood-brain barrier.

Robin Polt, Frank Porreca, Lajos Szabó, +6

Proceedings of the National Academy of Sciences

NeuropeptidesPain MedicineMolecular PainGlycopeptide Enkephalin AnaloguesPharmacotherapy +20

Probes for Narcotic Receptor Mediated Phenomena. 19. Synthesis of (+)-4-[(.alpha.R)-.alpha.-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC 80): A Highly Selective, Nonpeptide .delta. Opioid Receptor Agonist

Silvia N. Calderon, Richard B. Rothman, Frank Porreca, +7

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryBiochemistryMedicineSnc 80 +13

SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist.

Edward J. Bilsky, Silvia N. Calderon, T Wang, +7

Journal of Pharmacology and Experimental Therapeutics

Enkephalin Glycopeptide Analogues Produce Analgesia with Reduced Dependence Liability

Edward J. Bilsky, Richard D. Egleton, Scott A. Mitchell, +10

Journal of Medicinal Chemistry

Afferent drive elicits ongoing pain in a model of advanced osteoarthritis

Alec Okun, Ping Liu, Peg Davis, +8

Pain

Pain TherapyPain MedicineAfferent Drive ElicitsMolecular PainPharmacotherapy +17

Topographically designed analogs of [cyclic] [D-Pen2,D-Pen5]enkephalin

Victor J. Hruby, Catherine A. Gehrig, L.‐F. KAO, +6

Journal of Medicinal Chemistry

Probes for Narcotic Receptor Mediated Phenomena. 23. Synthesis, Opioid Receptor Binding, and Bioassay of the Highly Selective δ Agonist (+)-4-[(α<i>R</i>)-α-((2<i>S</i>,5<i>R</i>)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]- <i>N</i>,<i>N</i>-diethylbenzamide (SNC 80) and Related Novel Nonpeptide δ Opioid Receptor Ligands

Silvia N. Calderon, Kenner C. Rice, Richard B. Rothman, +9

Journal of Medicinal Chemistry

Synthesis, Opioid Receptor Binding, and Biological Activities of Naltrexone-Derived Pyrido- and Pyrimidomorphinans

Subramaniam Ananthan, Hollis S. Kezar, Ronald L. Carter, +9

Journal of Medicinal Chemistry

Topographical requirements for delta opioid ligands: Common structural features of dermenkephalin and deltorphin

Aleksandra Misicka, Andrzej W. Lipkowski, Róbert Horváth, +4

Life Sciences

Molecular NeuroscienceFunctional SelectivityMedicineMechanism Of ActionNeuropeptide Receptor +9

Ring substituted and other conformationally constrained tyrosine analogs of [cyclic] [D-Pen2,D-Pen5]enkephalin with .delta.-opioid receptor selectivity

Géza Tóth, Keith C. Russell, Geoffrey A. Landis, +7

Journal of Medicinal Chemistry