SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice

Hongwei Yao, Sangwoon Chung, Jae‐Woong Hwang, +9

Journal of Clinical Investigation

Advanced Lung DiseaseLung InflammationImmunologyCell DeathCopd Patients +14

Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM

Hongwei Yao, Gnanapragasam Arunachalam, Jae‐Woong Hwang, +5

Proceedings of the National Academy of Sciences

Extracellular Superoxide DismutaseInflammatory Lung DiseaseLung InflammationLipid PeroxidationImmunology +16

Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury <i>via</i> a SIRT1‐BMAL1 pathway

Jae‐Woong Hwang, Isaac K. Sundar, Hongwei Yao, +2

The FASEB Journal

Circadian Clock FunctionInflammatory Lung DiseaseLung InflammationImmunologyLocomotor Activity +16

FOXO3 Deficiency Leads to Increased Susceptibility to Cigarette Smoke-Induced Inflammation, Airspace Enlargement, and Chronic Obstructive Pulmonary Disease

Jae‐Woong Hwang, R. Saravanan, Hongwei Yao, +6

The Journal of Immunology

Acute Lung InjuryInflammatory Lung DiseaseLung InflammationImmunologyImmune Regulation +19

Cigarette smoke-induced autophagy is regulated by SIRT1–PARP-1-dependent mechanism: Implication in pathogenesis of COPD

Jae‐Woong Hwang, Sangwoon Chung, Isaac K. Sundar, +4

Archives of Biochemistry and Biophysics

Tobacco ControlCell AutophagyAllergyCigarette Smoke-induced AutophagyImmunology +7

High aldehyde dehydrogenase activity enhances stem cell features in breast cancer cells by activating hypoxia-inducible factor-2α

Ran‐Ju Kim, Jeong-Ran Park, Kyung‐Jin Roh, +12

Cancer Letters

Tumor BiologyAldehyde DehydrogenaseBiochemistryHypoxia-inducible Factor-2αMedicine +11

Rescue of high-specificity Cas9 variants using sgRNAs with matched 5’ nucleotides

Sojung Kim, Taegeun Bae, Jae‐Woong Hwang, +1

Genome biology

SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD

Hongwei Yao, Jae‐Woong Hwang, Isaac K. Sundar, +6

American Journal of Physiology-Lung Cellular and Molecular Physiology

InflammationSirt1 DeficiencyAllergyAdvanced Lung DiseaseLung Inflammation +12

Influenza A virus-dependent remodeling of pulmonary clock function in a mouse model of COPD

Isaac K. Sundar, Tanveer Ahmad, Hongwei Yao, +5

Scientific Reports

Nrf2 deficiency influences susceptibility to steroid resistance via HDAC2 reduction

David Adenuga, Samuel Caito, Hongwei Yao, +4

Biochemical and Biophysical Research Communications

Metabolic SyndromeHdac2 ReductionBiochemistryMedicineLipid Peroxidation +8