Understanding the Selectivity of Genistein for Human Estrogen Receptor-β Using X-Ray Crystallography and Computational Methods

Eric S. Manas, Zhang B. Xu, Rayomand J. Unwalla, +1

Structure

Molecular PharmacologyBiochemistryG Protein-coupled ReceptorMedicineNatural Sciences +8

Structure-Based Design of Estrogen Receptor-β Selective Ligands

Eric S. Manas, Rayomand J. Unwalla, Zhang B. Xu, +13

Journal of the American Chemical Society

Medicinal ChemistryBiochemistryFunctional SelectivityNatural SciencesMedicine +11

Optimization of 3-(1<i>H</i>-Indazol-3-ylmethyl)-1,5-benzodiazepines as Potent, Orally Active CCK-A Agonists

Brad R. Henke, Christopher Aquino, Larry S. Birkemo, +15

Journal of Medicinal Chemistry

ERβ ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor β-selective ligands

A. T. Vu, Alison N. Campbell, Heather A. Harris, +3

Bioorganic & Medicinal Chemistry Letters

BiochemistryMedicineHormonal ReceptorErβ LigandsReceptor (Biochemistry) +3

Molecular and Pharmacological Properties of a Potent and Selective Novel Nonsteroidal Progesterone Receptor Agonist Tanaproget

Zhiming Zhang, Andrea Olland, Yuan Zhu, +12

Journal of Biological Chemistry

Indazole-Based Liver X Receptor (LXR) Modulators with Maintained Atherosclerotic Lesion Reduction Activity but Diminished Stimulation of Hepatic Triglyceride Synthesis

Jay Wrobel, Robert J. Steffan, Susan Bowen, +20

Journal of Medicinal Chemistry

Estrogen receptor ligands: design and synthesis of new 2-arylindene-1-ones

Robert McDevitt, Michael S. Malamas, Eric S. Manas, +4

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicineDrug DiscoveryHormonal ReceptorChemistry +2

Insights for Predicting Blood-Brain Barrier Penetration of CNS Targeted Molecules Using QSPR Approaches

Yi Fan, Rayomand J. Unwalla, R. Aldrin Denny, +4

Journal of Chemical Information and Modeling

Drug TargetBrain PenetrationSecretase InhibitorsNeurochemical BiomarkersPre-clinical Pharmacology +20

Improvement of Physiochemical Properties of the Tetrahydroazepinoindole Series of Farnesoid X Receptor (FXR) Agonists: Beneficial Modulation of Lipids in Primates

Joseph T. Lundquist, Douglas C. Harnish, Callain Y. Kim, +16

Journal of Medicinal Chemistry

Crystal StructurePharmaceutical ScienceFarnesoid X ReceptorPharmacotherapyTetrahydroazepinoindole Series +14

Discovery of Phenyl Acetic Acid Substituted Quinolines as Novel Liver X Receptor Agonists for the Treatment of Atherosclerosis

Baihua Hu, Michael D. Collini, Rayomand J. Unwalla, +21

Journal of Medicinal Chemistry

Medicinal ChemistryPharmaceutical ChemistryPharmaceutical ScienceQuinolines 15Biochemistry +12