Activation of the Human Asparagine Synthetase Gene by the Amino Acid Response and the Endoplasmic Reticulum Stress Response Pathways Occurs by Common Genomic Elements

Ione Parra Barbosa‐Tessmann, Chin Chen, Can Zhong, +4

Journal of Biological Chemistry

GeneticsMolecular GeneticsAmino Acid DeprivationProtein SynthesisTranscriptional Regulation +20

Differences in the Molecular Mechanisms Involved in the Transcriptional Activation of the CHOP and Asparagine Synthetase Genes in Response to Amino Acid Deprivation or Activation of the Unfolded Protein Response

Alain Bruhat, Julien Avérous, Valérie Carraro, +4

Journal of Biological Chemistry

GeneticsMolecular BiologyMolecular GeneticsAmino Acid DeprivationProtein Synthesis +15

CCAAT/Enhancer-binding Protein-β Is a Mediator of the Nutrient-sensing Response Pathway That Activates the Human Asparagine Synthetase Gene

Fai Siu, Chin Chen, Can Zhong, +1

Journal of Biological Chemistry

Characterization of the amino acid response element within the human sodium-coupled neutral amino acid transporter 2 (SNAT2) System A transporter gene

Stela S. Palii, Michelle M. Thiaville, Yuan‐Xiang Pan, +2

Biochemical Journal

Activation of the Unfolded Protein Response Pathway Induces Human Asparagine Synthetase Gene Expression

Ione Parra Barbosa‐Tessmann, Chin Chen, Can Zhong, +3

Journal of Biological Chemistry

MEK Signaling Is Required for Phosphorylation of eIF2α following Amino Acid Limitation of HepG2 Human Hepatoma Cells

Michelle M. Thiaville, Yuan‐Xiang Pan, Altin Gjymishka, +3

Journal of Biological Chemistry

Mek SignalingMolecular RegulationCellular PhysiologyAmino Acid DeprivationSignaling Pathway +17

Human CCAAT/Enhancer-binding Protein β Gene Expression Is Activated by Endoplasmic Reticulum Stress through an Unfolded Protein Response Element Downstream of the Protein Coding Sequence

Chin Chen, Elizabeth E. Dudenhausen, Yuan‐Xiang Pan, +2

Journal of Biological Chemistry

Molecular BiologyEndoplasmic Reticulum StressTranscriptional RegulationGlucose DeprivationProtein Expression +15

Deprivation of protein or amino acid induces C/EBPβ synthesis and binding to amino acid response elements, but its action is not an absolute requirement for enhanced transcription

Michelle M. Thiaville, Elizabeth E. Dudenhausen, Can Zhong, +2

Biochemical Journal

Characterization of the nutrient-sensing response unit in the human asparagine synthetase promoter

Can Zhong, Chin Chen, Michael S. Kilberg

Biochemical Journal

Activated transcription via mammalian amino acid response elements does not require enhanced recruitment of the Mediator complex

Michelle M. Thiaville, Elizabeth E. Dudenhausen, Keytam S. Awad, +3

Nucleic Acids Research

Rna ProcessingTranscriptional RegulationAmino Acid LimitationProtein ExpressionNatural Sciences +13