Silvia Mandel

Green tea polyphenol (–)‐epigallocatechin‐3‐gallate prevents <i>N</i>‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐induced dopaminergic neurodegeneration

Yona Levites, Orly Weinreb, Gila Maor et al. · Journal of Neurochemistry · 2001 · 563 citations

Striatal Dopamine, Neurodegenerative Diseases, Green Tea Extract +11

Involvement of Protein Kinase C Activation and Cell Survival/ Cell Cycle Genes in Green Tea Polyphenol (−)-Epigallocatechin 3-Gallate Neuroprotective Action

Yona Levites, Tamar Amit, Moussa B. H. Youdim et al. · Journal of Biological Chemistry · 2002 · 415 citations · Full text

Neuroprotection and neurorescue against Aβ toxicity and PKC‐dependent release of non‐amyloidogenic soluble precursor protein by green tea polyphenol (‐)‐epigallocatechin‐3‐gallate

Yona Levites, Tamar Amit, Silvia Mandel et al. · The FASEB Journal · 2003 · 373 citations

Gene expression profiling of parkinsonian substantia nigra pars compacta; alterations in ubiquitin-proteasome, heat shock protein, iron and oxidative stress regulated proteins, cell adhesion/cellular matrix and vesicle trafficking genes

E. Gr�nblatt, Silvia Mandel, Jasmine Jacob‐Hirsch et al. · Journal of Neural Transmission · 2004 · 357 citations

Heat Shock Protein, Mitophagy, Protein Function +8

Attenuation of 6-hydroxydopamine (6-OHDA)-induced nuclear factor-kappaB (NF-κB) activation and cell death by tea extracts in neuronal cultures11Abbreviations: BT, Black Tea; EMSA, Electromobility Shift Assay; EGCG, (-)-Epigallocatechin-3-gallate; GT, Green Tea; NB SH-SY5Y cells, Human neuroblastoma SH-SY5Y cells; 6-OHDA, 6-hydroxydopamine; IL, Interleukin; LDH, Lactate Dehydrogenase; MPTP, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; NF-κB, nuclear factor-κB; OS, Oxidative Stress; PD, Parkinson’s Disease; ROS, Reactive Oxygen Species; SNPC, Substantia Nigra Pars Compacta; TBARS, thiobarbituric acid reactive substances.

Yona Levites, Moussa B. H. Youdim, Gila Maor et al. · Biochemical Pharmacology · 2002 · 292 citations