Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation

Lan Wu, Edward Seung, Ling Xu, +32

Nature Cancer

Tumor ImmunologyTumor-directed T CellsCancer ImmunosurveillanceImmunologyTherapeutic Efficacy +6

A trispecific antibody targeting HER2 and T cells inhibits breast cancer growth via CD4 cells

Edward Seung, Zhen Xing, Lan Wu, +25

Nature

Trispecific AntibodyBreast Cancer GrowthBreast OncologyImmunologyAntigen Processing +5

Mouse and human CD8⁺ CD28^low regulatory T lymphocytes differentiate in the thymus

Yirajen Vuddamalay, Mehdi Attia, Rita Vicente, +6

Immunology

Intrathymic transplantation of bone marrow–derived progenitors provides long-term thymopoiesis

Rita Vicente, Oumeya Adjali, Chantal Jacquet, +2

Blood

Intrathymic administration of hematopoietic progenitor cells enhances T cell reconstitution in ZAP-70 severe combined immunodeficiency

Oumeya Adjali, Rita Vicente, Christophe Ferrand, +6

Proceedings of the National Academy of Sciences

Cell TherapyLymphocyte DevelopmentT Cell ReconstitutionT-regulatory CellImmunology +15

Autoimmune regulator (AIRE)-deficient CD8⁺CD28^lowregulatory T lymphocytes fail to control experimental colitis

Celine Pomié, Rita Vicente, Yirajen Vuddamalay, +8

Proceedings of the National Academy of Sciences

T-regulatory CellImmune RegulationImmunologyRegulatory T CellsCd4 T Cell Responses +20

Efficient Intrathymic Gene Transfer Following In Situ Administration of a rAAV Serotype 8 Vector in Mice and Nonhuman Primates

Aurélie Moreau, Rita Vicente, Laurence Dubreil, +9

Molecular Therapy

ImmunologyNonhuman PrimatesThymus TransductionHuman RetrovirusSitu Administration +17

Lentiviral Transduction of Immune Cells

Louise Swainson, Cédric Mongellaz, Oumeya Adjali, +2

Innate Immunity

ImmunologyImmunodominanceImmunotherapeuticsExtensive Ex VivoImmunotherapy +17

Nonclassical CD4+CD49b+ Regulatory T Cells as a Better Alternative to Conventional CD4+CD25+ T Cells To Dampen Arthritis Severity

Rita Vicente, Julie Quentin, Anne-Laure Mausset-Bonnefont, +5

The Journal of Immunology

T-regulatory CellImmunologyImmune RegulationRegulatory T CellsBetter Alternative +20

Polymeric micelles based on poly(methacrylic acid) block-containing copolymers with different membrane destabilizing properties for cellular drug delivery

Naila Mebarek, Anne Aubert‐Pouëssel, Corine Gérardin, +3

International Journal of Pharmaceutics

Cellular Drug DeliveryEngineeringPolymer-drug ConjugatePolymer ScienceMicelle +7