The new‐generation pan‐peroxisome proliferator‐activated receptor agonist IVA337 protects the liver from metabolic disorders and fibrosis

Guillaume Wettstein, Jean‐Michel Luccarini, Laurence Poekes, +17

Hepatology Communications

Design, Synthesis, and Evaluation of a Novel Series of Indole Sulfonamide Peroxisome Proliferator Activated Receptor (PPAR) α/γ/δ Triple Activators: Discovery of Lanifibranor, a New Antifibrotic Clinical Candidate

Benaı̈ssa Boubia, Olivia Poupardin, Martine Barth, +21

Journal of Medicinal Chemistry

Pharmaceutical SciencePharmacotherapyPharmaceutical ChemistryTranslational PharmacologyPre-clinical Pharmacology +17

Pan PPAR agonist IVA337 is effective in prevention and treatment of experimental skin fibrosis

Nadira Ruzehaji, C. Frantz, Matthieu Ponsoye, +7

Annals of the Rheumatic Diseases

Pan-PPAR agonist IVA337 is effective in experimental lung fibrosis and pulmonary hypertension

Jérôme Avouac, Irena Konstantinova, Christophe Guignabert, +9

Annals of the Rheumatic Diseases

Design and Synthesis of Potent Bradykinin Agonists Containing a Benzothiazepine Moiety

Muriel Amblard, Isabelle Daffix, Philippe Bedos, +7

Journal of Medicinal Chemistry

Combinatorial ChemistryOrganic ChemistryPharmacotherapyHeterocycle ChemistryPharmaceutical Chemistry +18

CD8+T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas

Leticia Laura Niborski, Paul Gueguen, Mengliang Ye, +21

Nature Communications

LF 16.0335, a novel potent and selective nonpeptide antagonist of the human bradykinin B₂ receptor

Didier Pruneau, Jean‐Michel Luccarini, Chantal Fouchet, +8

British Journal of Pharmacology

Molecular PharmacologyMolecular PhysiologyLf 16.0335BiochemistryMedicine +13

Synthesis and Characterization of Bradykinin B₂ Receptor Agonists Containing Constrained Dipeptide Mimics

Muriel Amblard, Isabelle Daffix, Gilbert Bergé, +7

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryBiochemistrySelective Bradykinin BMedicine +13

Characterisation of bradykinin receptors from juvenile pig coronary artery

Didier Pruneau, Jean‐Michel Luccarini, Evelyne Defrêne, +2

European Journal of Pharmacology

Molecular PhysiologyCardiovascular DiseaseMedicinePhysiologyReceptor (Biochemistry) +4

A Rational Approach to the Design and Synthesis of a New Bradykinin B₁ Receptor Antagonist

Philippe Bedos, Muriel Amblard, Gilles Subra, +6

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryBradykinin Receptor AntagonistBiochemistryFunctional Selectivity +13