Safety and Efficacy of Chimeric Yellow Fever-Dengue Virus Tetravalent Vaccine Formulations in Nonhuman Primates

Farshad Guirakhoo, Z. Zhang, Gene Myers, +15

Journal of Virology

Synthetic VirologyImmunologyDen Virus SerotypesNonhuman PrimatesPathogen Discovery +14

Viremia and Immunogenicity in Nonhuman Primates of a Tetravalent Yellow Fever–Dengue Chimeric Vaccine: Genetic Reconstructions, Dose Adjustment, and Antibody Responses against Wild-type Dengue Virus Isolates

Farshad Guirakhoo, Juan Arroyo, Catherine Miller, +7

Virology

VaccinationDose AdjustmentVaccine DevelopmentGenetic ReconstructionsImmunology +5

Single Mutation in the Flavivirus Envelope Protein Hinge Region Increases Neurovirulence for Mice and Monkeys but Decreases Viscerotropism for Monkeys: Relevance to Development and Safety Testing of Live, Attenuated Vaccines

Thomas P. Monath, Juan Arroyo, Inessa S. Levenbook, +4

Journal of Virology

Chimeric Yellow Fever Virus 17D-Japanese Encephalitis Virus Vaccine: Dose-Response Effectiveness and Extended Safety Testing in Rhesus Monkeys

Thomas P. Monath, Inessa S. Levenbook, Kenneth F. Soike, +8

Journal of Virology

Cutaneous Delivery of a Live, Attenuated Chimeric Flavivirus Vaccines against Japanese Encephalitis (ChimeriVaxTM-JE) in Non-Human Primates

Cheryl H. Dean, Jason B. Alarcon, Andrea M. Waterston, +5

Human Vaccines

VaccinationMucosal VaccinationFlaviviral DiseasesVaccine DevelopmentChimeric Je Vaccine +11

Herpes simplex virus mRNA species mapping in EcoRI fragment I

Lucinda M. C. Hall, Ken Draper, R J Frink, +2

Journal of Virology

Viral ReplicationMolecular BiologyVirus StructureEcori FragmentDetailed Characterization +15

High-resolution characterization of herpes simplex virus type 1 transcripts encoding alkaline exonuclease and a 50,000-dalton protein tentatively identified as a capsid protein

Robert H. Costa, Ken Draper, Lawrence Banks, +4

Journal of Virology

Viral ReplicationCapsid ProteinImmunologyMolecular BiologyAlkaline Exonuclease +16

Characterization of the genes encoding herpes simplex virus type 1 and type 2 alkaline exonucleases and overlapping proteins

Ken Draper, G B Devi-Rao, Robert H. Costa, +3

Journal of Virology

Viral ReplicationAmino AcidsMolecular BiologyMolecular GeneticsViral Structural Protein +16

An unusual spliced herpes simplex virus type 1 transcript with sequence homology to Epstein-Barr virus DNA

Robert H. Costa, Ken Draper, Thomas J. Kelly, +1

Journal of Virology

Viral ReplicationGeneticsMolecular BiologyPathologyEpstein-barr Virus Genome +14

Safety testing for neurovirulence of novel live, attenuated flavivirus vaccines: Infant mice provide an accurate surrogate for the test in monkeys

Thomas P. Monath, Gwendolyn A. Myers, Robert A. Beck, +11

Biologicals

VaccinationAccurate SurrogateVaccine DevelopmentInfant MiceNeurovirology +9