Hypothalamic corticotropin-releasing hormone is a mediator of the anorexigenic effect of leptin.

Yutaka Uehara, Hiroyuki Shimizu, K Ohtani, +2

Diabetes

NutritionHypothalamic Corticotropin-releasing HormoneNeuroendocrinologyFood IntakeHypothalamic Circuits +22

Identification of a New Series of STAT3 Inhibitors by Virtual Screening

Kenji Matsuno, Yoshiaki Masuda, Yutaka Uehara, +14

ACS Medicinal Chemistry Letters

Akt2 phosphorylates Synip to regulate docking and fusion of GLUT4-containing vesicles

Eijiro Yamada, Shuichi Okada, Tsugumichi Saito, +6

The Journal of Cell Biology

Molecular BiologySynip Serine 99Cellular PhysiologyInsulin SignalingSignaling Pathway +16

Differential Activation of Epidermal Growth Factor (EGF) Receptor Downstream Signaling Pathways by Betacellulin and EGF

Tsugumichi Saito, Shuichi Okada, Kihachi Ohshima, +6

Endocrinology

Epidermal Growth FactorSignal TransductionDevelopmental BiologySignaling PathwayBtc Stimulation +12

Chronic insulin hypoglycemia induces GLUT-3 protein in rat brain neurons

Yutaka Uehara, Valerie Nipper, Anthony L. McCall

American Journal of Physiology-Endocrinology and Metabolism

Novel high-throughput screening system for identifying STAT3–SH2 antagonists

Yutaka Uehara, Masato Mochizuki, Kenji Matsuno, +2

Biochemical and Biophysical Research Communications

Hit IdentificationMedicineHigh-throughput ScreeningPharmacologyDrug Discovery +1

Molecular mechanisms associated with leptin resistance: n-3 polyunsaturated fatty acids induce alterations in the tight junction of the brain

Shinsuke Oh‐I, Hiroyuki Shimizu, Tetsurou Sato, +3

Cell Metabolism

NeuropeptidesGastrointestinal Peptide HormoneMolecular PhysiologyTight JunctionPhysiology +7

The significance of decreased ambulatory activity during the generation by long-term observation of obesity in ovariectomized rats

Yohnosuke Shimomura, Hiroyuki Shimizu, Masaki Takahashi, +6

Physiology & Behavior

ObesityMetabolic SyndromeEnergy HomeostasisEndocrine MechanismPhysiology +7

Leptin Stimulates Insulin Secretion and Synthesis in HIT-T 15 Cells

Hiroyuki Shimizu, Ken-Ichi Ohtani, Takahumi Tsuchiya, +4

Peptides

NeuropeptidesSignal TransductionHit-t 15DiabetesImmunology +8

CDK5-dependent Phosphorylation of the Rho Family GTPase TC10α Regulates Insulin-stimulated GLUT4 Translocation

Shuichi Okada, Eijiro Yamada, Tsugumichi Saito, +12

Journal of Biological Chemistry