A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone

Sung‐Wuk Jang, Xia Liu, Manuel Yepes, +8

Proceedings of the National Academy of Sciences

Brain-derived Neurotrophic FactorNeurodegenerative DiseasesSelective Trkb AgonistMedicineParkinson Disease +13

A Synthetic 7,8-Dihydroxyflavone Derivative Promotes Neurogenesis and Exhibits Potent Antidepressant Effect

Xia Liu, Chi-Bun Chan, Sung‐Wuk Jang, +9

Journal of Medicinal Chemistry

Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death

Sung‐Wuk Jang, Masashi Okada, Iqbal Sayeed, +4

Proceedings of the National Academy of Sciences

Cell DeathNeuroinflammationReceptor Tyrosine KinaseNeurologyNeuroimmunology +15

Amitriptyline is a TrkA and TrkB Receptor Agonist that Promotes TrkA/TrkB Heterodimerization and Has Potent Neurotrophic Activity

Sung-Wuk Jang, Xia Liu, Chi Bun Chan, +4

Chemistry & Biology

Molecular PharmacologySignal TransductionFunctional SelectivityMedicineReceptor (Biochemistry) +8

2,5-Bis[4-(<i>N</i>-alkylamidino)phenyl]furans as Anti-<i>Pneumocystis carinii</i> Agents

David W. Boykin, Arvind Kumar, Ge� Xiao, +5

Journal of Medicinal Chemistry

Deoxygedunin, a Natural Product with Potent Neurotrophic Activity in Mice

Sung‐Wuk Jang, Xia Liu, Chi Bun Chan, +9

PLoS ONE

O-Methylated Metabolite of 7,8-Dihydroxyflavone Activates TrkB Receptor and Displays Antidepressant Activity

Xia Liu, Qi Qi, Ge� Xiao, +3

Pharmacology

Optimization of a Small Tropomyosin-Related Kinase B (TrkB) Agonist 7,8-Dihydroxyflavone Active in Mouse Models of Depression

Xia Liu, Chi-Bun Chan, Qi Qi, +4

Journal of Medicinal Chemistry

PharmacotherapyLead Optimization CampaignExperimental PharmacologyMedicinal ChemistryMouse Models +16

Synthesis of substituted 5[H]phenanthridin-6-ones as potent poly(ADP-ribose)polymerase-1 (PARP1) inhibitors

Jia-He Li, L.S. Serdyuk, Dana Ferraris, +7

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineDrug DevelopmentPharmacologySubstituted 5 +1

Blockade of Glioma Proliferation Through Allosteric Inhibition of JAK2

Kunyan He, Qi Qi, Chi-Bun Chan, +13

Science Signaling

Janus Kinase 2GliomaTumor BiologyNeuro-oncologySignaling Pathway +14