T.D. Bethke

Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD

Diana C. Grootendorst, Stefanie A. Gauw, Renate M. Verhoosel et al. · Thorax · 2007 · 281 citations · Full text

Roflumilast—An oral anti-inflammatory treatment for chronic obstructive pulmonary disease: A randomised controlled trial

Klaus F. Rabe, E.D. Bateman, Denis E. O’Donnell et al. · Respiratory Medicine COPD Update · 2005 · 69 citations

Asthma, Inflammation, Antifibrotic Therapy +6

Phosphodiesterase inhibition by enoximone in preparations from nonfailing and failing human hearts.

T.D. Bethke, Thomas Eschenhagen, Anna Klimkiewicz et al. · PubMed · 1992 · 30 citations

Cardiac Muscle, Heart Failure, Pde Isoenzymes +16

High Selectivity for Inhibition of Phosphodiesterase III and Positive Inotropic Effects of MCI-154 in Guinea Pig Myocardium

T.D. Bethke, Wieland Meyer, Wilhelm Schmitz et al. · Journal of Cardiovascular Pharmacology · 1993 · 24 citations

Cardiac Muscle, Muscle Function, Pde Iv +21

Effects of Isomazole on Force of Contraction and Phosphodiesterase Isoenzymes I-IV in Nonfailing and Failing Human Hearts

T.D. Bethke, Anna Klimkiewicz, Claudia Kohl et al. · Journal of Cardiovascular Pharmacology · 1991 · 23 citations

Cardiac Muscle, Heart Failure, Pde Iv +18