Sudhakar Manda

A marine sponge alkaloid derivative 4-chloro fascaplysin inhibits tumor growth and VEGF mediated angiogenesis by disrupting PI3K/Akt/mTOR signaling cascade

Sonia Sharma, Santosh Kumar Guru, Sudhakar Manda et al. · Chemico-Biological Interactions · 2017 · 80 citations

Tumor Biology, Angiogenesis, Medicine +8

Discovery of a marine-derived bis-indole alkaloid fascaplysin, as a new class of potent P-glycoprotein inducer and establishment of its structure–activity relationship

Sudhakar Manda, Sadhana Sharma, Abubakar Wani et al. · European Journal of Medicinal Chemistry · 2015 · 74 citations · Full text

Structure–activity Relationship, Natural Product Synthesis, Biochemistry +9

Fascaplysin Induces Caspase Mediated Crosstalk Between Apoptosis and Autophagy Through the Inhibition of PI3K/AKT/mTOR Signaling Cascade in Human Leukemia HL‐60 Cells

Suresh Kumar, Santosh Kumar Guru, Anup S. Pathania et al. · Journal of Cellular Biochemistry · 2015 · 65 citations

Total synthesis and anti-cholinesterase activity of marine-derived bis-indole alkaloid fascaplysin

Sandip B. Bharate, Sudhakar Manda, Prashant Joshi et al. · MedChemComm · 2012 · 59 citations

Fascaplysin Accommodates, Molecular Pharmacology, Diversity Oriented Synthesis +12

Synthesis, antileishmanial and antitrypanosomal activities of N-substituted tetrahydro-β-carbolines

Sudhakar Manda, Shabana I. Khan, Surendra Jain et al. · Bioorganic & Medicinal Chemistry Letters · 2014 · 47 citations

Medicinal Chemistry, Bioorganic Chemistry, Antitrypanosomal Activities +5